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    FAM210A family with sequence similarity 210 member A [ Homo sapiens (human) ]

    Gene ID: 125228, updated on 17-Jun-2024

    Summary

    Official Symbol
    FAM210Aprovided by HGNC
    Official Full Name
    family with sequence similarity 210 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:28346
    See related
    Ensembl:ENSG00000177150 MIM:617975; AllianceGenome:HGNC:28346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT2329; C18orf19
    Summary
    Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart (RPKM 6.1), testis (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FAM210A in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (13663347..13726558, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13826182..13888908, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13663346..13726557, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene uncharacterized LOC124904256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474525-13475024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474023-13474524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493407-13493936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493937-13494464 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13500239-13500896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13541887-13542410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13542411-13542932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13548044-13548993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13550257-13550758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13566667-13567294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613793-13614310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613273-13613792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13616337-13616838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13623209-13623708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13626114-13626614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649057-13649558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649559-13650058 Neighboring gene microRNA 4526 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13672949-13674148 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13675367-13676566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13688247-13688792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13725735-13726660 Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13775047-13775546 Neighboring gene RNA guanine-7 methyltransferase Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13823817-13823997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9336 Neighboring gene melanocortin 5 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC24180

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein FAM210A
    Names
    uncharacterized protein C18orf19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098801.2NP_001092271.1  protein FAM210A

      See identical proteins and their annotated locations for NP_001092271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA602175, AP001010, BU189118, DA560663, DA573992
      Consensus CDS
      CCDS11866.1
      UniProtKB/Swiss-Prot
      D3DUJ4, Q96ND0
      UniProtKB/TrEMBL
      K7EK00
      Conserved Domains (1) summary
      pfam06916
      Location:124211
      DUF1279; Protein of unknown function (DUF1279)
    2. NM_152352.4NP_689565.2  protein FAM210A

      See identical proteins and their annotated locations for NP_689565.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA602175, AP001010, BU189118, DA573992, DA895646
      Consensus CDS
      CCDS11866.1
      UniProtKB/Swiss-Prot
      D3DUJ4, Q96ND0
      UniProtKB/TrEMBL
      K7EK00
      Related
      ENSP00000498370.1, ENST00000651643.1
      Conserved Domains (1) summary
      pfam06916
      Location:124211
      DUF1279; Protein of unknown function (DUF1279)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      13663347..13726558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451083.2XP_024306851.1  protein FAM210A isoform X1

      UniProtKB/Swiss-Prot
      D3DUJ4, Q96ND0
      UniProtKB/TrEMBL
      K7EK00
      Conserved Domains (1) summary
      pfam06916
      Location:124211
      DUF1279; Protein of unknown function (DUF1279)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      13826182..13888908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318175.1XP_054174150.1  protein FAM210A isoform X1

      UniProtKB/Swiss-Prot
      D3DUJ4, Q96ND0
      UniProtKB/TrEMBL
      K7EK00