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    Cd44 CD44 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12505, updated on 1-Jul-2024

    Summary

    Official Symbol
    Cd44provided by MGI
    Official Full Name
    CD44 antigenprovided by MGI
    Primary source
    MGI:MGI:88338
    See related
    Ensembl:ENSMUSG00000005087 AllianceGenome:MGI:88338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly-24; Pgp-1; HERMES
    Summary
    Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 13.1), spleen adult (RPKM 8.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd44 in Genome Data Viewer
    Location:
    2 E2; 2 54.13 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (102641486..102732014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (102811141..102901669, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05258 Neighboring gene predicted gene, 57687 Neighboring gene solute carrier family 1 (glial high affinity glutamate transporter), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2631 Neighboring gene predicted gene 13872 Neighboring gene STARR-positive B cell enhancer mm9_chr2:102635439-102635740 Neighboring gene STARR-seq mESC enhancer starr_05259 Neighboring gene STARR-positive B cell enhancer ABC_E3387 Neighboring gene STARR-positive B cell enhancer ABC_E5950 Neighboring gene STARR-seq mESC enhancer starr_05260 Neighboring gene STARR-seq mESC enhancer starr_05261 Neighboring gene STARR-seq mESC enhancer starr_05262 Neighboring gene predicted gene, 23731 Neighboring gene STARR-positive B cell enhancer ABC_E9522 Neighboring gene STARR-positive B cell enhancer ABC_E2632 Neighboring gene predicted gene, 34483 Neighboring gene STARR-positive B cell enhancer ABC_E5951 Neighboring gene STARR-positive B cell enhancer ABC_E5952 Neighboring gene STARR-positive B cell enhancer mm9_chr2:102913613-102913914 Neighboring gene pyruvate dehydrogenase complex, component X

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (9) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hyaluronic acid binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type II transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hyaluronan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mature B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within wound healing involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of macrophage migration inhibitory factor receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of macrophage migration inhibitory factor receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of macrophage migration inhibitory factor receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD44 antigen
    Names
    ECMR-III
    GP90 lymphocyte homing/adhesion receptor
    HUTCH-I
    PGP-I
    extracellular matrix receptor III
    hermes antigen
    hyaluronate receptor
    lymphocyte antigen 24
    phagocytic glycoprotein 1
    phagocytic glycoprotein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039150.1NP_001034239.1  CD44 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_001034239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
      Source sequence(s)
      AL844155, CT010324
      Consensus CDS
      CCDS16470.1
      UniProtKB/TrEMBL
      E9QKM8, Q80X37
      Related
      ENSMUSP00000062330.8, ENSMUST00000060516.14
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    2. NM_001039151.1NP_001034240.1  CD44 antigen isoform c precursor

      See identical proteins and their annotated locations for NP_001034240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
      Source sequence(s)
      AK045226, AL844155
      Consensus CDS
      CCDS16471.1
      UniProtKB/TrEMBL
      Q3U468, Q3U8S1, Q3UNN2
      Related
      ENSMUSP00000097265.3, ENSMUST00000099673.9
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    3. NM_001177785.1NP_001171256.1  CD44 antigen isoform d precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
      Source sequence(s)
      AJ251594, AK045226, AL844155
      Consensus CDS
      CCDS50650.1
      UniProtKB/TrEMBL
      A2APM1, E9QKM8
      Related
      ENSMUSP00000106829.3, ENSMUST00000111198.9
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    4. NM_001177786.1NP_001171257.1  CD44 antigen isoform e precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
      Source sequence(s)
      AJ251594, AK045226, AL844155
      Consensus CDS
      CCDS50649.1
      UniProtKB/TrEMBL
      A2APM4, A2APM5
      Related
      ENSMUSP00000106822.3, ENSMUST00000111191.9
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    5. NM_001177787.1NP_001171258.1  CD44 antigen isoform f precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several alternate, in-frame, exons, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
      Source sequence(s)
      AJ251594, AK045226, AL844155
      Consensus CDS
      CCDS50648.1
      UniProtKB/TrEMBL
      A2APM3, A2APM5
      Related
      ENSMUSP00000106821.3, ENSMUST00000111190.9
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    6. NM_009851.2NP_033981.2  CD44 antigen isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
      Source sequence(s)
      AJ251594, AK045226, AL844155
      Consensus CDS
      CCDS16472.1
      UniProtKB/Swiss-Prot
      P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
      UniProtKB/TrEMBL
      A2APM2
      Related
      ENSMUSP00000005218.9, ENSMUST00000005218.15
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      102641486..102732014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498649.2XP_006498712.1  CD44 antigen isoform X4

      UniProtKB/TrEMBL
      E9QKM8
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    2. XM_006498647.2XP_006498710.1  CD44 antigen isoform X2

      UniProtKB/Swiss-Prot
      P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    3. XM_006498646.2XP_006498709.1  CD44 antigen isoform X1

      UniProtKB/Swiss-Prot
      P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8
      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
    4. XM_006498648.2XP_006498711.1  CD44 antigen isoform X3

      Conserved Domains (1) summary
      cd03516
      Location:30173
      Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...