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    Entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Mus musculus (house mouse) ]

    Gene ID: 12497, updated on 31-Jul-2021

    Summary

    Official Symbol
    Entpd6provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 6provided by MGI
    Primary source
    MGI:MGI:1202295
    See related
    Ensembl:ENSMUSG00000033068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd39l; NTPDa; Cd39l2; NTPDase-6; 2700026H11Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 27.5), genital fat pad adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Entpd6 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150590959..150613595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150748980..150771675)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (150574817..150597410)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene RIKEN cDNA E130215H24 gene Neighboring gene visual system homeobox 1 Neighboring gene predicted gene, 30141 Neighboring gene uncharacterized LOC118568526 Neighboring gene brain glycogen phosphorylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytidine-diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanosine-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanosine-diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inosine-diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleoside-diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside-triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables uridine-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables uridine-diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 6
    Names
    CD39 antigen-like 2
    NTPDase 6
    NP_001341997.1
    NP_001357558.1
    NP_001357559.1
    NP_001357560.1
    NP_742115.2
    XP_017170703.1
    XP_030102887.1
    XP_030102889.1
    XP_030102891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355068.1NP_001341997.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845174
      Consensus CDS
      CCDS16861.1
      Conserved Domains (1) summary
      cl17037
      Location:71448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_001370629.1NP_001357558.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. NM_001370630.1NP_001357559.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. NM_001370631.1NP_001357560.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71207
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. NM_172117.5NP_742115.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      See identical proteins and their annotated locations for NP_742115.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845174
      Consensus CDS
      CCDS16861.1
      UniProtKB/TrEMBL
      Q3U0P5
      Related
      ENSMUSP00000092038.6, ENSMUST00000094467.6
      Conserved Domains (1) summary
      cl17037
      Location:71448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150590959..150613595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247031.2XP_030102891.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1228
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_017315214.3XP_017170703.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1228
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. XM_030247029.1XP_030102889.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:71448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. XM_030247027.2XP_030102887.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:71448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_003950191.2 RNA Sequence

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