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    Noct nocturnin [ Mus musculus (house mouse) ]

    Gene ID: 12457, updated on 26-Sep-2022

    Summary

    Official Symbol
    Noctprovided by MGI
    Official Full Name
    nocturninprovided by MGI
    Primary source
    MGI:MGI:109382
    See related
    Ensembl:ENSMUSG00000023087 AllianceGenome:MGI:109382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccr4; Ccrn4l
    Summary
    Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly; circadian rhythm; and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 54.9), colon adult (RPKM 24.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Noct in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51131868..51159075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51224447..51251654)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35891 Neighboring gene predicted gene, 40044 Neighboring gene RIKEN cDNA 4930577N17 gene Neighboring gene E74-like factor 2 Neighboring gene nuclear encoded tRNA proline 7 (anticodon TGG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADPH phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nocturnin
    Names
    CCR4 carbon catabolite repression 4-like
    CCR4 protein homolog
    carbon catabolite repression 4 homolog
    carbon catabolite repression 4-like protein
    circadian deadenylase NOC
    NP_033964.1
    XP_006501019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009834.2NP_033964.1  nocturnin

      See identical proteins and their annotated locations for NP_033964.1

      Status: VALIDATED

      Source sequence(s)
      AK084516, AK087790, BB261546
      Consensus CDS
      CCDS17336.1
      UniProtKB/Swiss-Prot
      O35710, Q9QZG9
      UniProtKB/TrEMBL
      B2RTJ8
      Related
      ENSMUSP00000023849.9, ENSMUST00000023849.15
      Conserved Domains (1) summary
      cd09096
      Location:142421
      Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51131868..51159075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500956.1XP_006501019.1  nocturnin isoform X1

      Conserved Domains (1) summary
      cd09096
      Location:85364
      Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains