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    Ccnt1 cyclin T1 [ Mus musculus (house mouse) ]

    Gene ID: 12455, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ccnt1provided by MGI
    Official Full Name
    cyclin T1provided by MGI
    Primary source
    MGI:MGI:1328363
    See related
    Ensembl:ENSMUSG00000011960 AllianceGenome:MGI:1328363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycT1; 2810478G24Rik
    Summary
    Enables chromatin binding activity; nucleic acid binding activity; and protein kinase binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation; positive regulation of DNA-templated transcription, elongation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; gonad; hemolymphoid system gland; and limb. Orthologous to human CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ccnt1 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98436570..98468340, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98538690..98567736, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene microRNA 1291 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene testis expressed 49 Neighboring gene adenylate cyclase 6 Neighboring gene calcium channel, voltage-dependent, beta 3 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of P-TEFb complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368702.1NP_001355631.1  cyclin-T1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138221
      Conserved Domains (1) summary
      cd00043
      Location:38109
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. NM_009833.2NP_033963.1  cyclin-T1 isoform 1

      See identical proteins and their annotated locations for NP_033963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138221
      Consensus CDS
      CCDS27797.1
      UniProtKB/Swiss-Prot
      Q9QWV9, Q9Z0U7
      Related
      ENSMUSP00000012104.7, ENSMUST00000012104.7
      Conserved Domains (1) summary
      pfam00134
      Location:13149
      Cyclin_N; Cyclin, N-terminal domain

    RNA

    1. NR_160872.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138221

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98436570..98468340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159107.1XP_036015000.1  cyclin-T1 isoform X1

      Conserved Domains (2) summary
      cd20595
      Location:10147
      CYCLIN_CCNT1_rpt1; first cyclin box found in cyclin-T1 (CCNT1)
      cl40454
      Location:151235
      CYCLIN_SF; Cyclin box fold superfamily