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    Ccne2 cyclin E2 [ Mus musculus (house mouse) ]

    Gene ID: 12448, updated on 12-Mar-2019

    Summary

    Official Symbol
    Ccne2provided by MGI
    Official Full Name
    cyclin E2provided by MGI
    Primary source
    MGI:MGI:1329034
    See related
    Ensembl:ENSMUSG00000028212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in liver E14 (RPKM 11.2), liver E14.5 (RPKM 8.4) and 13 other tissues See more
    Orthologs

    Genomic context

    See Ccne2 in Genome Data Viewer
    Location:
    4; 4 A1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (11190298..11204779)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (11118501..11131926)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene microRNA 684-2 Neighboring gene transformation related protein 53 inducible nuclear protein 1 Neighboring gene RIKEN cDNA A630034I12 gene Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19-like 4 (C. elegans) Neighboring gene epithelial splicing regulatory protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome organization involved in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapsis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapsis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin E2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin E2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin E2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037134.2NP_001032211.1  G1/S-specific cyclin-E2 isoform 1

      See identical proteins and their annotated locations for NP_001032211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK010929, AK031116, AK158720
      Consensus CDS
      CCDS17965.1
      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      Q544H6
      Related
      ENSMUSP00000130693.1, ENSMUST00000170901.7
      Conserved Domains (2) summary
      pfam00134
      Location:112239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241361
      Cyclin_C; Cyclin, C-terminal domain
    2. NM_001282943.1NP_001269872.1  G1/S-specific cyclin-E2 isoform 1

      See identical proteins and their annotated locations for NP_001269872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK010929, AK031116, AK158720, AL840625
      Consensus CDS
      CCDS17965.1
      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      Q544H6
      Related
      ENSMUSP00000103960.3, ENSMUST00000108324.3
      Conserved Domains (2) summary
      pfam00134
      Location:112239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241361
      Cyclin_C; Cyclin, C-terminal domain
    3. NM_009830.3NP_033960.1  G1/S-specific cyclin-E2 isoform 2

      See identical proteins and their annotated locations for NP_033960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK031116, AL840625
      Consensus CDS
      CCDS17966.1
      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      A2API1
      Related
      ENSMUSP00000029866.9, ENSMUST00000029866.15
      Conserved Domains (2) summary
      pfam00134
      Location:111238
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:240360
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      11190298..11204779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537574.3XP_006537637.1  G1/S-specific cyclin-E2 isoform X1

      See identical proteins and their annotated locations for XP_006537637.1

      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      Q544H6
      Conserved Domains (2) summary
      pfam00134
      Location:112239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241361
      Cyclin_C; Cyclin, C-terminal domain
    2. XM_006537575.3XP_006537638.1  G1/S-specific cyclin-E2 isoform X2

      See identical proteins and their annotated locations for XP_006537638.1

      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      A2API1
      Conserved Domains (2) summary
      pfam00134
      Location:111238
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:240360
      Cyclin_C; Cyclin, C-terminal domain
    3. XM_011249913.2XP_011248215.1  G1/S-specific cyclin-E2 isoform X2

      See identical proteins and their annotated locations for XP_011248215.1

      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      A2API1
      Conserved Domains (2) summary
      pfam00134
      Location:111238
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:240360
      Cyclin_C; Cyclin, C-terminal domain
    4. XM_006537573.3XP_006537636.1  G1/S-specific cyclin-E2 isoform X1

      See identical proteins and their annotated locations for XP_006537636.1

      UniProtKB/Swiss-Prot
      Q9Z238
      UniProtKB/TrEMBL
      Q544H6
      Conserved Domains (2) summary
      pfam00134
      Location:112239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241361
      Cyclin_C; Cyclin, C-terminal domain
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