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    Ccnd3 cyclin D3 [ Mus musculus (house mouse) ]

    Gene ID: 12445, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ccnd3provided by MGI
    Official Full Name
    cyclin D3provided by MGI
    Primary source
    MGI:MGI:88315
    See related
    Ensembl:ENSMUSG00000034165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C78795; AA682053; AL024085; AW146355; 9230106B05Rik
    Expression
    Broad expression in thymus adult (RPKM 402.8), adrenal adult (RPKM 319.1) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccnd3 in Genome Data Viewer
    Location:
    17 C; 17 23.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47815976..47910614)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47505051..47599689)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (47642000..47736638)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001C19 gene Neighboring gene expressed sequence AI661453 Neighboring gene TATA-box binding protein associated factor 8 Neighboring gene VISTA enhancer mm1691 Neighboring gene predicted gene, 41590 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene mediator complex subunit 20 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene translocase of outer mitochondrial membrane 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081635.1NP_001075104.1  G1/S-specific cyclin-D3

      See identical proteins and their annotated locations for NP_001075104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 3. Variant 2 encodes the same protein as variant 3.
      Source sequence(s)
      AK159503, AK161758, AK210362, BQ033424, BY146822, M86183
      Consensus CDS
      CCDS28850.1
      UniProtKB/Swiss-Prot
      P30282
      UniProtKB/TrEMBL
      Q3TSW4, Q3TWY0
      Related
      ENSMUSP00000040488.10, ENSMUST00000037333.17
      Conserved Domains (1) summary
      cl40454
      Location:2151
      CYCLIN_SF; Cyclin box fold superfamily
    2. NM_001081636.1NP_001075105.1  G1/S-specific cyclin-D3

      See identical proteins and their annotated locations for NP_001075105.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK159503, AK161758, AK210362, BQ033424, BY146822, M86183
      Consensus CDS
      CCDS28850.1
      UniProtKB/Swiss-Prot
      P30282
      UniProtKB/TrEMBL
      Q3TSW4, Q3TWY0
      Related
      ENSMUSP00000126141.2, ENSMUST00000171031.8
      Conserved Domains (1) summary
      cl40454
      Location:2151
      CYCLIN_SF; Cyclin box fold superfamily
    3. NM_007632.2NP_031658.1  G1/S-specific cyclin-D3

      See identical proteins and their annotated locations for NP_031658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variant 1 encodes the same protein as variant 3.
      Source sequence(s)
      AK159503, AK210362, BQ033424, BY142612, M86183
      Consensus CDS
      CCDS28850.1
      UniProtKB/Swiss-Prot
      P30282
      UniProtKB/TrEMBL
      Q3TSW4, Q3TWY0
      Related
      ENSMUSP00000138091.2, ENSMUST00000182209.8
      Conserved Domains (1) summary
      cl40454
      Location:2151
      CYCLIN_SF; Cyclin box fold superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47815976..47910614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523552.2XP_006523615.1  G1/S-specific cyclin-D3 isoform X1

      Conserved Domains (1) summary
      cl40454
      Location:92196
      CYCLIN_SF; Cyclin box fold superfamily
    2. XM_011246262.1XP_011244564.1  G1/S-specific cyclin-D3 isoform X3

      See identical proteins and their annotated locations for XP_011244564.1

      Conserved Domains (2) summary
      pfam00134
      Location:19105
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:107203
      Cyclin_C; Cyclin, C-terminal domain
    3. XM_006523553.5XP_006523616.1  G1/S-specific cyclin-D3 isoform X2

      UniProtKB/TrEMBL
      S4R216
      Related
      ENSMUSP00000138458.2, ENSMUST00000182539.8
      Conserved Domains (1) summary
      pfam02984
      Location:155
      Cyclin_C; Cyclin, C-terminal domain
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