Format

Send to:

Choose Destination
    • Showing Current items.

    Ccna2 cyclin A2 [ Mus musculus (house mouse) ]

    Gene ID: 12428, updated on 5-Mar-2019

    Summary

    Official Symbol
    Ccna2provided by MGI
    Official Full Name
    cyclin A2provided by MGI
    Primary source
    MGI:MGI:108069
    See related
    Ensembl:ENSMUSG00000027715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccn1; Ccna; Cyca; Ccn-1; CycA2; AA408589
    Expression
    Broad expression in liver E14 (RPKM 91.0), liver E14.5 (RPKM 83.6) and 15 other tissues See more
    Orthologs

    Genomic context

    See Ccna2 in Genome Data Viewer
    Location:
    3 B; 3 17.67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (36564865..36573025, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (36463787..36470918, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11549 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 (human) Neighboring gene transient receptor potential cation channel, subfamily C, member 3 Neighboring gene predicted gene, 35856

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin A2-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin A2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-A2
    Names
    Cyclin A2 (Cyclin A)
    cyclin-A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009828.3NP_033958.2  cyclin-A2

      See identical proteins and their annotated locations for NP_033958.2

      Status: VALIDATED

      Source sequence(s)
      AC117584, AK044924, BC052730
      Consensus CDS
      CCDS17313.1
      UniProtKB/Swiss-Prot
      P51943
      Related
      ENSMUSP00000029270.3, ENSMUST00000029270.9
      Conserved Domains (3) summary
      pfam00134
      Location:171297
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:299417
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:22152
      Cyclin_N2; N-terminal region of cyclin_N

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      36564865..36573025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319444.1XP_017174933.1  cyclin-A2 isoform X1

      UniProtKB/Swiss-Prot
      P51943
      Conserved Domains (3) summary
      pfam00134
      Location:171297
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:299417
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:22152
      Cyclin_N2; N-terminal region of cyclin_N
    Support Center