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    Rb1cc1 RB1-inducible coiled-coil 1 [ Mus musculus (house mouse) ]

    Gene ID: 12421, updated on 28-Aug-2021

    Summary

    Official Symbol
    Rb1cc1provided by MGI
    Official Full Name
    RB1-inducible coiled-coil 1provided by MGI
    Primary source
    MGI:MGI:1341850
    See related
    Ensembl:ENSMUSG00000025907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cc1; Fip2; LaXp; FIP200; LaXp180; 2900055E04Rik; 5930404L04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.4), cerebellum adult (RPKM 5.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rb1cc1 in Genome Data Viewer
    Location:
    1; 1 A1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (6284858..6346599)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (6214634..6276375)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (6204743..6266185)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene COP9 (constitutive photomorphogenic) homolog, subunit 2 pseudogene Neighboring gene predicted gene, 46206 Neighboring gene ALK and LTK ligand 1 Neighboring gene uncharacterized protein C9orf40 homolog pseudogene Neighboring gene motile sperm domain containing 1 pseudogene Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Atg1/ULK1 kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Atg1/ULK1 kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Atg1/ULK1 kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RB1-inducible coiled-coil protein 1
    Names
    200 kDa FAK family kinase-interacting protein
    FAK family kinase-interacting protein of 200 kDa
    coiled-coil-forming protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009826.4NP_033956.2  RB1-inducible coiled-coil protein 1

      See identical proteins and their annotated locations for NP_033956.2

      Status: VALIDATED

      Source sequence(s)
      AB070619, AK033709, AK041038, CN720888
      Consensus CDS
      CCDS35507.1
      UniProtKB/Swiss-Prot
      Q9ESK9
      Related
      ENSMUSP00000027040.7, ENSMUST00000027040.13
      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:14561582
      ATG11; Autophagy-related protein 11

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      6284858..6346599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238338.3XP_011236640.1  RB1-inducible coiled-coil protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011236640.1

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061600
      ATG11; Autophagy-related protein 11
    2. XM_011238341.4XP_011236643.1  RB1-inducible coiled-coil protein 1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061597
      ATG11; Autophagy-related protein 11
    3. XM_006495443.5XP_006495506.1  RB1-inducible coiled-coil protein 1 isoform X4

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:14561579
      ATG11; Autophagy-related protein 11
    4. XM_036156298.1XP_036012191.1  RB1-inducible coiled-coil protein 1 isoform X5

      Conserved Domains (2) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
    5. XM_036156334.1XP_036012227.1  RB1-inducible coiled-coil protein 1 isoform X7

      Conserved Domains (2) summary
      COG0419
      Location:6441175
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10377
      Location:12581384
      ATG11; Autophagy-related protein 11
    6. XM_036156326.1XP_036012219.1  RB1-inducible coiled-coil protein 1 isoform X6

      Conserved Domains (2) summary
      COG0419
      Location:6441175
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10377
      Location:13081402
      ATG11; Autophagy-related protein 11
    7. XM_011238339.2XP_011236641.1  RB1-inducible coiled-coil protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011236641.1

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061600
      ATG11; Autophagy-related protein 11
    8. XM_011238340.2XP_011236642.1  RB1-inducible coiled-coil protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011236642.1

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061600
      ATG11; Autophagy-related protein 11
    9. XM_036156270.1XP_036012163.1  RB1-inducible coiled-coil protein 1 isoform X3

      Related
      ENSMUSP00000125348.2, ENSMUST00000161327.8
      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:14561582
      ATG11; Autophagy-related protein 11
    10. XM_036156247.1XP_036012140.1  RB1-inducible coiled-coil protein 1 isoform X1

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061600
      ATG11; Autophagy-related protein 11
    11. XM_036156243.1XP_036012136.1  RB1-inducible coiled-coil protein 1 isoform X1

      Conserved Domains (3) summary
      COG0419
      Location:8421373
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd17060
      Location:276
      Ubl_RB1CC1; ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins
      pfam10377
      Location:15061600
      ATG11; Autophagy-related protein 11
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