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    Cbx2 chromobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 12416, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cbx2provided by MGI
    Official Full Name
    chromobox 2provided by MGI
    Primary source
    MGI:MGI:88289
    See related
    Ensembl:ENSMUSG00000025577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pc; M33; MOD2
    Summary
    This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See Cbx2 in Genome Data Viewer
    Location:
    11 E2; 11 83.33 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (119023019..119031275)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (118884343..118892584)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35710 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 Neighboring gene predicted gene, 35829 Neighboring gene chromobox 8 Neighboring gene chromobox 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    development of primary sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chromobox protein homolog 2
    Names
    M33 polycomb-like protein
    chromobox homolog 2
    modifier 3 protein
    polycomb

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007623.3NP_031649.2  chromobox protein homolog 2

      See identical proteins and their annotated locations for NP_031649.2

      Status: REVIEWED

      Source sequence(s)
      AK141647, BE986063, CJ176395, X62537
      Consensus CDS
      CCDS25708.1
      UniProtKB/Swiss-Prot
      P30658
      UniProtKB/TrEMBL
      Q3URA3
      Related
      ENSMUSP00000026662.7, ENSMUST00000026662.7
      Conserved Domains (1) summary
      pfam00385
      Location:1561
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      119023019..119031275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532104.1XP_006532167.1  chromobox protein homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam00385
      Location:1561
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
    2. XM_006532103.1XP_006532166.1  chromobox protein homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam17218
      Location:553585
      CBX7_C; CBX family C-terminal motif
    3. XM_006532105.1XP_006532168.1  chromobox protein homolog 2 isoform X3

      Conserved Domains (1) summary
      pfam17218
      Location:492524
      CBX7_C; CBX family C-terminal motif
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