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    Cbx1 chromobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 12412, updated on 6-Sep-2021

    Summary

    Official Symbol
    Cbx1provided by MGI
    Official Full Name
    chromobox 1provided by MGI
    Primary source
    MGI:MGI:105369
    See related
    Ensembl:ENSMUSG00000018666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbx; HP1; M31; MOD; HP1B; MOD1; Cbx-r; Hp1be; Cbx-rs2; Hp1beta; E430007M08Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 39.9), CNS E14 (RPKM 17.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cbx1 in Genome Data Viewer
    Location:
    11 D; 11 60.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96679506..96699808)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96788680..96808982)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96650450..96669954)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 1 Neighboring gene predicted gene, 38960 Neighboring gene sorting nexin 11 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene nuclear factor, erythroid derived 2,-like 1 Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in female pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chromobox protein homolog 1
    Names
    chromobox homolog 1
    heterochromatin protein 1 homolog beta
    heterochromatin protein p25
    modifier 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362560.1NP_001349489.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Consensus CDS
      CCDS25303.1
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cd18654
      Location:112169
      CSD_HP1beta_Cbx1; chromo shadow domain of heterochromatin protein 1 homolog beta
    2. NM_001362561.1NP_001349490.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Consensus CDS
      CCDS25303.1
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cd18654
      Location:112169
      CSD_HP1beta_Cbx1; chromo shadow domain of heterochromatin protein 1 homolog beta
    3. NM_001362563.1NP_001349492.1  chromobox protein homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596384
      Consensus CDS
      CCDS25303.1
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cd18654
      Location:112169
      CSD_HP1beta_Cbx1; chromo shadow domain of heterochromatin protein 1 homolog beta
    4. NM_001362564.1NP_001349493.1  chromobox protein homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK017608, AL596384
      Consensus CDS
      CCDS88236.1
      Related
      ENSMUSP00000078640.4, ENSMUST00000079702.4
      Conserved Domains (2) summary
      pfam00385
      Location:2770
      Chromo; Chromo (CHRromatin Organisation MOdifier) domain
      cl00044
      Location:111139
      ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...
    5. NM_007622.4NP_031648.1  chromobox protein homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_031648.1

      Status: VALIDATED

      Source sequence(s)
      AK014215, AL596384
      Consensus CDS
      CCDS25303.1
      UniProtKB/Swiss-Prot
      P83917
      Related
      ENSMUSP00000091475.4, ENSMUST00000093943.10
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cd18654
      Location:112169
      CSD_HP1beta_Cbx1; chromo shadow domain of heterochromatin protein 1 homolog beta

    RNA

    1. NR_155761.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596384, BC055290
      Related
      ENSMUST00000134585.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96679506..96699808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314242.2XP_017169731.1  chromobox protein homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      P83917
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cd18654
      Location:112169
      CSD_HP1beta_Cbx1; chromo shadow domain of heterochromatin protein 1 homolog beta
    2. XM_006532102.3XP_006532165.1  chromobox protein homolog 1 isoform X2

      Related
      ENSMUSP00000018810.4, ENSMUST00000018810.10
      Conserved Domains (2) summary
      cd18650
      Location:2069
      CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
      cl28914
      Location:112137
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    RNA

    1. XR_003949269.1 RNA Sequence

    2. XR_003949267.1 RNA Sequence

    3. XR_003949268.1 RNA Sequence

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