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    Cbfa2t2 CBFA2/RUNX1 translocation partner 2 [ Mus musculus (house mouse) ]

    Gene ID: 12396, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cbfa2t2provided by MGI
    Official Full Name
    CBFA2/RUNX1 translocation partner 2provided by MGI
    Primary source
    MGI:MGI:1333833
    See related
    Ensembl:ENSMUSG00000038533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTGR1; Cbfa2t2h; A430091M07; C330013D05Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 10.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cbfa2t2 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (154436463..154539356)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (154262220..154365092)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene syntrophin, acidic 1 Neighboring gene predicted gene, 39962 Neighboring gene zinc finger, FYVE domain containing 21 pseudogene Neighboring gene RIKEN cDNA 1700003F12 gene Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene actin-like 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein CBFA2T2
    Names
    CBFA2T2 identified gene homolog
    MTG8-like protein
    MTG8-related protein 1
    core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285446.1NP_001272375.1  protein CBFA2T2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL772292
      Conserved Domains (3) summary
      pfam01753
      Location:281317
      zf-MYND; MYND finger
      pfam08788
      Location:105171
      NHR2; NHR2 domain like
      cl27055
      Location:212280
      MutS_III; MutS domain III
    2. NM_009823.1NP_033953.1  protein CBFA2T2 isoform 2

      See identical proteins and their annotated locations for NP_033953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AK040403, AK148027, BC064679
      Consensus CDS
      CCDS50764.1
      UniProtKB/Swiss-Prot
      O70374
      UniProtKB/TrEMBL
      A0A0R4J1D5, Q3UGB2
      Related
      ENSMUSP00000105347.1, ENSMUST00000109725.7
      Conserved Domains (4) summary
      pfam01753
      Location:497533
      zf-MYND; MYND finger
      pfam07531
      Location:106192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322388
      NHR2; NHR2 domain like
      cl27055
      Location:433496
      MutS_III; MutS domain III
    3. NM_172860.2NP_766448.1  protein CBFA2T2 isoform 1

      See identical proteins and their annotated locations for NP_766448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK148027, BC064679
      Consensus CDS
      CCDS16932.1
      UniProtKB/Swiss-Prot
      O70374
      UniProtKB/TrEMBL
      Q3UGB2
      Related
      ENSMUSP00000043087.8, ENSMUST00000045270.14
      Conserved Domains (4) summary
      pfam01753
      Location:498534
      zf-MYND; MYND finger
      pfam07531
      Location:106192
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:322388
      NHR2; NHR2 domain like
      cl27055
      Location:429497
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      154436463..154539356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498642.2XP_006498705.1  protein CBFA2T2 isoform X3

      Conserved Domains (4) summary
      pfam01753
      Location:324360
      zf-MYND; MYND finger
      pfam03763
      Location:256307
      Remorin_C; Remorin, C-terminal region
      pfam07531
      Location:106171
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:171214
      NHR2; NHR2 domain like
    2. XM_006498641.1XP_006498704.1  protein CBFA2T2 isoform X2

      Conserved Domains (4) summary
      pfam01753
      Location:450486
      zf-MYND; MYND finger
      pfam03763
      Location:382433
      Remorin_C; Remorin, C-terminal region
      pfam07531
      Location:58144
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:274340
      NHR2; NHR2 domain like
    3. XM_006498640.2XP_006498703.1  protein CBFA2T2 isoform X1

      See identical proteins and their annotated locations for XP_006498703.1

      UniProtKB/Swiss-Prot
      O70374
      Conserved Domains (4) summary
      pfam01753
      Location:478514
      zf-MYND; MYND finger
      pfam03763
      Location:410461
      Remorin_C; Remorin, C-terminal region
      pfam07531
      Location:86172
      TAFH; NHR1 homology to TAF
      pfam08788
      Location:302368
      NHR2; NHR2 domain like
    4. XM_011239268.2XP_011237570.1  protein CBFA2T2 isoform X4

      Related
      ENSMUSP00000118371.1, ENSMUST00000137526.1
      Conserved Domains (3) summary
      pfam01753
      Location:230266
      zf-MYND; MYND finger
      pfam03763
      Location:162213
      Remorin_C; Remorin, C-terminal region
      pfam08788
      Location:54120
      NHR2; NHR2 domain like
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