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    Casp3 caspase 3 [ Mus musculus (house mouse) ]

    Gene ID: 12367, updated on 14-Sep-2021

    Summary

    Official Symbol
    Casp3provided by MGI
    Official Full Name
    caspase 3provided by MGI
    Primary source
    MGI:MGI:107739
    See related
    Ensembl:ENSMUSG00000031628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ya; AC-; CC3; CPP; mld; AC-3; Casp; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik
    Summary
    This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in CNS E18 (RPKM 54.1), CNS E14 (RPKM 37.8) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Casp3 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47070326..47092733)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46617291..46639698)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (47702803..47724071)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene centromere protein U Neighboring gene primase and polymerase (DNA-directed) Neighboring gene predicted gene 45607 Neighboring gene predicted gene, 31111 Neighboring gene predicted gene, 16675

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables death receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables phospholipase A2 activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to staurosporine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within execution phase of apoptosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to UV IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    caspase-3
    Names
    SREBP cleavage activity 1
    apopain
    caspase 3, apoptosis related cysteine protease
    cysteine protease CPP32
    protein Yama
    NP_001271338.1
    NP_033940.1
    XP_017168032.1
    XP_030099126.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284409.1NP_001271338.1  caspase-3

      See identical proteins and their annotated locations for NP_001271338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC119267
      Consensus CDS
      CCDS22294.1
      UniProtKB/Swiss-Prot
      P70677
      Related
      ENSMUSP00000147767.2, ENSMUST00000211115.2
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    2. NM_009810.3NP_033940.1  caspase-3

      See identical proteins and their annotated locations for NP_033940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC119267
      Consensus CDS
      CCDS22294.1
      UniProtKB/Swiss-Prot
      P70677
      Related
      ENSMUSP00000091238.6, ENSMUST00000093517.7
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      47070326..47092733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312543.3XP_017168032.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      P70677
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    2. XM_030243266.1XP_030099126.1  caspase-3 isoform X1

      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
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