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    Capza1 capping protein (actin filament) muscle Z-line, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12340, updated on 5-Sep-2021

    Summary

    Official Symbol
    Capza1provided by MGI
    Official Full Name
    capping protein (actin filament) muscle Z-line, alpha 1provided by MGI
    Primary source
    MGI:MGI:106227
    See related
    Ensembl:ENSMUSG00000070372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca; CAPZ; CAZ1; Cappa1; capZ alpha-1
    Expression
    Ubiquitous expression in placenta adult (RPKM 33.2), testis adult (RPKM 31.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Capza1 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104730097..104771821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104822781..104864505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (104625703..104667423, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ras homolog family member C Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene Neighboring gene wingless-type MMTV integration site family, member 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of F-actin capping protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-actin-capping protein subunit alpha-1
    Names
    F-actin capping protein alpha-1 subunit
    capping protein alpha 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355044.1NP_001341973.1  F-actin-capping protein subunit alpha-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Conserved Domains (1) summary
      pfam01267
      Location:17214
      F-actin_cap_A; F-actin capping protein alpha subunit
    2. NM_009797.3NP_033927.2  F-actin-capping protein subunit alpha-1 isoform 1

      See identical proteins and their annotated locations for NP_033927.2

      Status: VALIDATED

      Source sequence(s)
      AK147049, AK161370, BC085506, BY442029, U16740
      Consensus CDS
      CCDS38580.1
      UniProtKB/TrEMBL
      Q5RKN9
      Related
      ENSMUSP00000102381.4, ENSMUST00000094028.10
      Conserved Domains (1) summary
      pfam01267
      Location:14282
      F-actin_cap_A; F-actin capping protein alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104730097..104771821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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