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    Capza1 capping protein (actin filament) muscle Z-line, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12340, updated on 16-Mar-2019

    Summary

    Official Symbol
    Capza1provided by MGI
    Official Full Name
    capping protein (actin filament) muscle Z-line, alpha 1provided by MGI
    Primary source
    MGI:MGI:106227
    See related
    Ensembl:ENSMUSG00000070372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAPZ; CAZ1; Cappa1; capZ alpha-1
    Expression
    Ubiquitous expression in placenta adult (RPKM 33.2), testis adult (RPKM 31.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Capza1 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (104822785..104864505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (104625703..104667423, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ras homolog family member C Neighboring gene Moloney leukemia virus 10 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene Neighboring gene wingless-type MMTV integration site family, member 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    F-actin capping protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    WASH complex ISO
    Inferred from Sequence Orthology
    more info
     
    actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-actin-capping protein subunit alpha-1
    Names
    F-actin capping protein alpha-1 subunit
    capping protein alpha 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355044.1NP_001341973.1  F-actin-capping protein subunit alpha-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Conserved Domains (1) summary
      pfam01267
      Location:17214
      F-actin_cap_A; F-actin capping protein alpha subunit
    2. NM_009797.3NP_033927.2  F-actin-capping protein subunit alpha-1 isoform 1

      See identical proteins and their annotated locations for NP_033927.2

      Status: VALIDATED

      Source sequence(s)
      AK147049, AK161370, BC085506, BY442029, U16740
      Consensus CDS
      CCDS38580.1
      UniProtKB/TrEMBL
      Q5RKN9
      Related
      ENSMUSP00000102381.3, ENSMUST00000094028.9
      Conserved Domains (1) summary
      pfam01267
      Location:14282
      F-actin_cap_A; F-actin capping protein alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      104822785..104864505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500946.2XP_006501009.1  F-actin-capping protein subunit alpha-1 isoform X1

      Conserved Domains (1) summary
      pfam01267
      Location:17214
      F-actin_cap_A; F-actin capping protein alpha subunit
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