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    Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12331, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cap1provided by MGI
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 1provided by MGI
    Primary source
    MGI:MGI:88262
    See related
    Ensembl:ENSMUSG00000028656 AllianceGenome:MGI:88262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cap1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122752841..122779869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122859048..122886076, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene STARR-seq mESC enhancer starr_11275 Neighboring gene predicted gene 12873 Neighboring gene STARR-seq mESC enhancer starr_11276 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122504971-122505172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122525696-122525897 Neighboring gene STARR-positive B cell enhancer ABC_E2709 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122549318-122549471 Neighboring gene STARR-seq mESC enhancer starr_11277 Neighboring gene STARR-seq mESC enhancer starr_11278 Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    CAP, adenylate cyclase-associated protein 1
    adenylyl cyclase-associated CAP protein, yeast homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301067.3NP_001287996.1  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_001287996.1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000068260.6, ENSMUST00000069533.12
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    2. NM_001358035.2NP_001344964.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101864.4, ENSMUST00000106257.10
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    3. NM_001358036.2NP_001344965.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    4. NM_001430094.1NP_001417023.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
    5. NM_001430095.1NP_001417024.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
    6. NM_001430096.1NP_001417025.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
    7. NM_007598.6NP_031624.2  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_031624.2

      Status: REVIEWED

      Source sequence(s)
      AL606906, BX545849
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124, Q8BPT7
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101862.2, ENSMUST00000106255.8
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      122752841..122779869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)