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    Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 12331, updated on 14-Sep-2021

    Summary

    Official Symbol
    Cap1provided by MGI
    Official Full Name
    CAP, adenylate cyclase-associated protein 1 (yeast)provided by MGI
    Primary source
    MGI:MGI:88262
    See related
    Ensembl:ENSMUSG00000028656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cap1 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122752841..122779869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122859048..122886076, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (122536471..122563124, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene predicted gene 12873 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene major facilitator superfamily domain containing 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    adenylyl cyclase-associated CAP protein, yeast homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301067.2NP_001287996.1  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_001287996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a 474 aa protein. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, AK171388, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124
      UniProtKB/TrEMBL
      Q3U0U5, Q3UVJ2
      Related
      ENSMUSP00000068260.6, ENSMUST00000069533.12
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    2. NM_001358035.1NP_001344964.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Consensus CDS
      CCDS18604.1
      Related
      ENSMUSP00000101864.4, ENSMUST00000106257.10
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    3. NM_001358036.1NP_001344965.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, BY309560, DN175073
      Consensus CDS
      CCDS18604.1
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    4. NM_007598.5NP_031624.2  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_031624.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101862.2, ENSMUST00000106255.8
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      122752841..122779869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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