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    Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 12331, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cap1provided by MGI
    Official Full Name
    CAP, adenylate cyclase-associated protein 1 (yeast)provided by MGI
    Primary source
    MGI:MGI:88262
    See related
    Ensembl:ENSMUSG00000028656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cap1 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (122859048..122886071, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (122536471..122563124, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene predicted gene 12873 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene major facilitator superfamily domain containing 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space HDA PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    adenylyl cyclase-associated CAP protein, yeast homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301067.2NP_001287996.1  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_001287996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a 474 aa protein. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, AK171388, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124
      UniProtKB/TrEMBL
      Q3U0U5, Q3UVJ2
      Related
      ENSMUSP00000068260.5, ENSMUST00000069533.11
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    2. NM_001358035.1NP_001344964.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    3. NM_001358036.1NP_001344965.1  adenylyl cyclase-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, BY309560, DN175073
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    4. NM_007598.5NP_031624.2  adenylyl cyclase-associated protein 1

      See identical proteins and their annotated locations for NP_031624.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AK053351, AK137222, DN175073
      Consensus CDS
      CCDS18604.1
      UniProtKB/Swiss-Prot
      P40124
      UniProtKB/TrEMBL
      Q3UVJ2
      Related
      ENSMUSP00000101862.1, ENSMUST00000106255.7
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      122859048..122886071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502695.1XP_006502758.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P40124
      Related
      ENSMUSP00000101864.3, ENSMUST00000106257.9
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    2. XM_006502697.3XP_006502760.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P40124
      Conserved Domains (2) summary
      pfam01213
      Location:7292
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:323472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
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