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    TARS3 threonyl-tRNA synthetase 3 [ Homo sapiens (human) ]

    Gene ID: 123283, updated on 3-Apr-2024

    Summary

    Official Symbol
    TARS3provided by HGNC
    Official Full Name
    threonyl-tRNA synthetase 3provided by HGNC
    Primary source
    HGNC:HGNC:24728
    See related
    Ensembl:ENSG00000185418 AllianceGenome:HGNC:24728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TARSL2; ThrRS-L
    Summary
    Predicted to enable threonine-tRNA ligase activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 4.4), heart (RPKM 3.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    Location:
    15q26.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101653596..101724473, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99411600..99482344, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102193799..102264676, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102152533-102153033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102153852-102154370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102154371-102154887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102157328-102157940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6891 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102186842-102187008 Neighboring gene TM2 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:102192988-102193878 Neighboring gene RNA, U6 small nuclear 807, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102215750-102216274 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:102216275-102216797 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6894 Neighboring gene UBE2Q2 pseudogene 13 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:102286622-102286992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:102303375-102304574 Neighboring gene dynamin 1 pseudogene 47

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in threonyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    threonine--tRNA ligase 2, cytoplasmic
    Names
    probable threonine--tRNA ligase 2, cytoplasmic
    probable threonyl-tRNA synthetase 2, cytoplasmic
    thrRS
    threonyl-tRNA synthetase like 2
    threonyl-tRNA synthetase protein 3
    threonyl-tRNA synthetase-like protein 2
    NP_689547.2
    XP_016877401.1
    XP_047288096.1
    XP_047288098.1
    XP_054233241.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152334.3NP_689547.2  threonine--tRNA ligase 2, cytoplasmic

      See identical proteins and their annotated locations for NP_689547.2

      Status: VALIDATED

      Source sequence(s)
      AC027559, AC090164, AK056653, AL833188, AW161214, BE856588, BU677165
      Consensus CDS
      CCDS10394.1
      UniProtKB/Swiss-Prot
      A2RTX5, B2RMP7, Q6B0A1, Q6IS76, Q96LW3, Q96MP4
      UniProtKB/TrEMBL
      B7ZLP8
      Related
      ENSP00000338093.3, ENST00000335968.8
      Conserved Domains (5) summary
      cd01667
      Location:162223
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:122795
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:329376
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:400697
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:697788
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      101653596..101724473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432142.1XP_047288098.1  threonine--tRNA ligase 2, cytoplasmic isoform X3

    2. XM_047432140.1XP_047288096.1  threonine--tRNA ligase 2, cytoplasmic isoform X1

      Related
      ENSP00000478827.1, ENST00000615656.1
    3. XM_017021912.3XP_016877401.1  threonine--tRNA ligase 2, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      B7ZLP8
      Conserved Domains (1) summary
      PLN02908
      Location:122655
      PLN02908; threonyl-tRNA synthetase

    RNA

    1. XR_007064422.1 RNA Sequence

    2. XR_931749.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      99411600..99482344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377266.1XP_054233241.1  threonine--tRNA ligase 2, cytoplasmic isoform X3