Format

Send to:

Choose Destination
    • Showing Current items.

    Camk2g calcium/calmodulin-dependent protein kinase II gamma [ Mus musculus (house mouse) ]

    Gene ID: 12325, updated on 31-Jan-2019

    Summary

    Official Symbol
    Camk2gprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase II gammaprovided by MGI
    Primary source
    MGI:MGI:88259
    See related
    Ensembl:ENSMUSG00000021820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camkg
    Expression
    Broad expression in cortex adult (RPKM 49.3), cerebellum adult (RPKM 39.7) and 26 other tissues See more
    Orthologs

    Genomic context

    See Camk2g in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (20734873..20794129, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (21554097..21613310, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene predicted gene, 30108 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 5930429P18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of relaxation of cardiac muscle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit gamma
    Names
    Ca2+/calmodulin-dependent protein kinase II
    CaMK II
    caMK-II subunit gamma
    NP_001034227.1
    NP_001034228.1
    NP_848712.2
    XP_006518551.1
    XP_006518552.1
    XP_006518553.1
    XP_006518554.1
    XP_006518555.1
    XP_006518556.1
    XP_006518557.1
    XP_006518558.1
    XP_006518559.1
    XP_006518560.1
    XP_006518561.1
    XP_006518563.1
    XP_017171315.1
    XP_017171316.1
    XP_017171317.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039138.2NP_001034227.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001034227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AF395884, AK031213, AK054406, AK078311, BY449383, CJ151263
      Consensus CDS
      CCDS26855.1
      UniProtKB/Swiss-Prot
      Q923T9
      UniProtKB/TrEMBL
      Q6ZWS7, Q8BW40
      Related
      ENSMUSP00000079298.6, ENSMUST00000080440.13
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. NM_001039139.2NP_001034228.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_001034228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK031213, AK078311, BY449383, CJ151263
      Consensus CDS
      CCDS26856.1
      UniProtKB/Swiss-Prot
      Q923T9
      UniProtKB/TrEMBL
      Q6ZWS7
      Related
      ENSMUSP00000098398.3, ENSMUST00000100837.10
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:363490
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. NM_001360186.1NP_001347115.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121599, AF395884, AK031213, AK054406, AK078311, BY449383, CJ151263
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:395522
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    4. NM_178597.5NP_848712.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_848712.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF395884, AK031213, AK054406, AK078311, BY449383, CJ151263
      Consensus CDS
      CCDS26857.1
      UniProtKB/Swiss-Prot
      Q923T9
      UniProtKB/TrEMBL
      Q6ZWS7, Q8BW40
      Related
      ENSMUSP00000071720.6, ENSMUST00000071816.6
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:397524
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      20734873..20794129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518489.2XP_006518552.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

      See identical proteins and their annotated locations for XP_006518552.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:445572
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. XM_006518488.2XP_006518551.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006518551.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:456583
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. XM_006518500.3XP_006518563.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

      Conserved Domains (3) summary
      smart00220
      Location:10190
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam08332
      Location:374501
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006518492.2XP_006518555.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

      See identical proteins and their annotated locations for XP_006518555.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:424551
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    5. XM_006518495.2XP_006518558.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

      Conserved Domains (3) summary
      smart00220
      Location:14272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:412539
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    6. XM_006518490.3XP_006518553.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

      See identical proteins and their annotated locations for XP_006518553.1

      Related
      ENSMUSP00000154158.1, ENSMUST00000226630.1
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:435562
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    7. XM_006518493.2XP_006518556.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

      See identical proteins and their annotated locations for XP_006518556.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:422549
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    8. XM_006518491.2XP_006518554.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

      See identical proteins and their annotated locations for XP_006518554.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:433560
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    9. XM_006518494.2XP_006518557.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

      See identical proteins and their annotated locations for XP_006518557.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:418545
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    10. XM_006518497.2XP_006518560.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

      See identical proteins and their annotated locations for XP_006518560.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:401528
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    11. XM_017315826.1XP_017171315.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:384511
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    12. XM_006518496.3XP_006518559.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

      See identical proteins and their annotated locations for XP_006518559.1

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:407534
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    13. XM_006518498.2XP_006518561.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:395522
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    14. XM_017315827.1XP_017171316.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:374501
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    15. XM_017315828.1XP_017171317.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

      Conserved Domains (2) summary
      pfam08332
      Location:234361
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_874287.2 RNA Sequence

    Support Center