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    Calr calreticulin [ Mus musculus (house mouse) ]

    Gene ID: 12317, updated on 19-Mar-2019

    Summary

    Official Symbol
    Calrprovided by MGI
    Official Full Name
    calreticulinprovided by MGI
    Primary source
    MGI:MGI:88252
    See related
    Ensembl:ENSMUSG00000003814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRT; Calregulin
    Expression
    Ubiquitous expression in placenta adult (RPKM 574.7), genital fat pad adult (RPKM 279.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Calr in Genome Data Viewer
    Location:
    8 C2; 8 41.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (84842088..84846931, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87365987..87370830, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene microRNA 7069

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    peptide antigen assembly with MHC class I protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    MHC class I peptide loading complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MHC class I peptide loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calreticulin
    Names
    CRP55
    ERp60
    HACBP
    endoplasmic reticulum resident protein 60

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007591.3NP_031617.1  calreticulin precursor

      See identical proteins and their annotated locations for NP_031617.1

      Status: VALIDATED

      Source sequence(s)
      AK075605, AK160197, BB727203, BY291864
      Consensus CDS
      CCDS22479.1
      UniProtKB/Swiss-Prot
      P14211
      UniProtKB/TrEMBL
      B2MWM9
      Related
      ENSMUSP00000003912.6, ENSMUST00000003912.6
      Conserved Domains (1) summary
      pfam00262
      Location:23332
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      84842088..84846931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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