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    Calm1 calmodulin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12313, updated on 31-Jan-2019

    Summary

    Official Symbol
    Calm1provided by MGI
    Official Full Name
    calmodulin 1provided by MGI
    Primary source
    MGI:MGI:88251
    See related
    Ensembl:ENSMUSG00000001175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CaM; Calm; Cam1; AI256814; AI327027; AI461935; AL024000
    Summary
    This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in cortex adult (RPKM 432.2), frontal lobe adult (RPKM 376.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Calm1 in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (100199435..100209824)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (101437751..101448016)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36263 Neighboring gene predicted gene 10433 Neighboring gene predicted gene, 40557 Neighboring gene predicted gene 10432 Neighboring gene tetratricopeptide repeat domain 7B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 3 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated potassium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    calmodulin-1
    NP_001300863.1
    NP_033920.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313934.1NP_001300863.1  calmodulin-1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC159633, AK145841, AW489089, BC054805
      Consensus CDS
      CCDS83995.1
      UniProtKB/Swiss-Prot
      P0DP26
      UniProtKB/TrEMBL
      Q3UKW2
      Related
      ENSMUSP00000001204.6, ENSMUST00000001204.6
      Conserved Domains (2) summary
      PTZ00184
      Location:50197
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:133195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_009790.5NP_033920.1  calmodulin-1 isoform 2

      See identical proteins and their annotated locations for NP_033920.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC159633, AK150978, AW489089, BC054805, BY294999
      Consensus CDS
      CCDS36523.1
      UniProtKB/Swiss-Prot
      P0DP26, P0DP27, P0DP28
      Related
      ENSMUSP00000105709.3, ENSMUST00000110082.10
      Conserved Domains (1) summary
      PTZ00184
      Location:1149
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      100199435..100209824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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