Format

Send to:

Choose Destination
    • Showing Current items.

    Pdia4 protein disulfide isomerase associated 4 [ Mus musculus (house mouse) ]

    Gene ID: 12304, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pdia4provided by MGI
    Official Full Name
    protein disulfide isomerase associated 4provided by MGI
    Primary source
    MGI:MGI:104864
    See related
    Ensembl:ENSMUSG00000025823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C; Cai; ERp; Erp72; ERp-72; AI987846
    Expression
    Ubiquitous expression in placenta adult (RPKM 75.3), genital fat pad adult (RPKM 46.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdia4 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47773075..47790446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47796141..47813512, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47746140..47763511, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 7 Neighboring gene RNA, Y1 small cytoplasmic, Ro-associated Neighboring gene microRNA 704 Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 398

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein disulfide-isomerase A4
    Names
    ER protein 72
    calcium binding protein, intestinal
    endoplasmic reticulum protein 72
    endoplasmic reticulum resident protein 72
    NP_001355685.1
    NP_033917.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368756.1NP_001355685.1  protein disulfide-isomerase A4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC166252
      Conserved Domains (2) summary
      TIGR01126
      Location:63164
      pdi_dom; protein disulfide-isomerase domain
      TIGR01130
      Location:173691
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    2. NM_009787.2NP_033917.2  protein disulfide-isomerase A4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_033917.2

      Status: VALIDATED

      Source sequence(s)
      AK161534, BC066857, CF165880
      Consensus CDS
      CCDS20097.1
      UniProtKB/Swiss-Prot
      P08003
      UniProtKB/TrEMBL
      A0A0R4J0Z1
      Related
      ENSMUSP00000076521.8, ENSMUST00000077290.9
      Conserved Domains (5) summary
      cd02995
      Location:522627
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03068
      Location:282388
      PDI_b_ERp72; PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as ...
      cd03073
      Location:393502
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01126
      Location:178279
      pdi_dom; protein disulfide-isomerase domain
      TIGR01130
      Location:173633
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47773075..47790446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center