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    SOCS4 suppressor of cytokine signaling 4 [ Homo sapiens (human) ]

    Gene ID: 122809, updated on 3-Apr-2024

    Summary

    Official Symbol
    SOCS4provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 4provided by HGNC
    Primary source
    HGNC:HGNC:19392
    See related
    Ensembl:ENSG00000180008 MIM:616337; AllianceGenome:HGNC:19392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SOCS7
    Summary
    The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 5.4), lymph node (RPKM 5.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SOCS4 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55027236..55049489)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49232425..49254678)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55493954..55516207)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:55364129-55364629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5776 Neighboring gene farnesyl diphosphate synthase pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 2393 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene ribosomal protein SA pseudogene 13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:55493639-55494166 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:55494167-55494693 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:55517727-55518416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5779 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8424 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:55543983-55545182 Neighboring gene uncharacterized LOC124903318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8425 Neighboring gene Sharpr-MPRA regulatory region 8345

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    suppressor of cytokine signaling 4
    Names
    SH2 domain containing SOCS box protein
    SOCS-4
    SOCS-7
    suppressor of cytokine signaling 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080867.3NP_543143.1  suppressor of cytokine signaling 4

      See identical proteins and their annotated locations for NP_543143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region, as compared to variant 1.
      Source sequence(s)
      AK126195, BC060790, BX161418, BX648734
      Consensus CDS
      CCDS9722.1
      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      B3KW39, Q5H9R6
      Related
      ENSP00000378855.2, ENST00000395472.2
      Conserved Domains (3) summary
      cd10385
      Location:275375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59111
      SOCS; Suppressor of cytokine signalling
    2. NM_199421.2NP_955453.1  suppressor of cytokine signaling 4

      See identical proteins and their annotated locations for NP_955453.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it has an additional exon in the 5' region.
      Source sequence(s)
      AK126195, BC060790, BX648734, CD109883
      Consensus CDS
      CCDS9722.1
      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      B3KW39, Q5H9R6
      Related
      ENSP00000452522.1, ENST00000555846.2
      Conserved Domains (3) summary
      cd10385
      Location:275375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59111
      SOCS; Suppressor of cytokine signalling

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      55027236..55049489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536425.2XP_011534727.1  suppressor of cytokine signaling 4 isoform X1

      See identical proteins and their annotated locations for XP_011534727.1

      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      B3KW39, Q5H9R6
      Conserved Domains (3) summary
      cd10385
      Location:275375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59111
      SOCS; Suppressor of cytokine signalling
    2. XM_011536426.2XP_011534728.1  suppressor of cytokine signaling 4 isoform X1

      See identical proteins and their annotated locations for XP_011534728.1

      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      B3KW39, Q5H9R6
      Conserved Domains (3) summary
      cd10385
      Location:275375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59111
      SOCS; Suppressor of cytokine signalling

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      49232425..49254678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375392.1XP_054231367.1  suppressor of cytokine signaling 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      Q5H9R6
    2. XM_054375393.1XP_054231368.1  suppressor of cytokine signaling 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8WXH5
      UniProtKB/TrEMBL
      Q5H9R6