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    C5ar1 complement component 5a receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12273, updated on 16-Jul-2019

    Summary

    Official Symbol
    C5ar1provided by MGI
    Official Full Name
    complement component 5a receptor 1provided by MGI
    Primary source
    MGI:MGI:88232
    See related
    Ensembl:ENSMUSG00000049130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C5aR; C5r1; Cd88; D7Msu1
    Expression
    Broad expression in lung adult (RPKM 10.0), mammary gland adult (RPKM 8.9) and 20 other tissues See more
    Orthologs

    Genomic context

    See C5ar1 in Genome Data Viewer
    Location:
    7 A2; 7 8.77 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (16246743..16259540, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16832092..16844889, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene complement component 5a receptor 2 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene BCL2 binding component 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    complement component C5a binding ISO
    Inferred from Sequence Orthology
    more info
     
    complement component C5a receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    complement component C5a receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    complement component C5a receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    complement receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    amyloid-beta clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation in hindbrain ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cognition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    complement component C5a signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    microglial cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    presynapse organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of tau-protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C5a anaphylatoxin chemotactic receptor 1
    Names
    C5a anaphylatoxin receptor
    C5a ligand
    C5a-R
    complement component 5, receptor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173550.1NP_001167021.1  C5a anaphylatoxin chemotactic receptor 1

      See identical proteins and their annotated locations for NP_001167021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS20846.1
      UniProtKB/Swiss-Prot
      P30993
      Related
      ENSMUSP00000129972.1, ENSMUST00000168818.1
      Conserved Domains (1) summary
      pfam00001
      Location:54301
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_007577.4NP_031603.2  C5a anaphylatoxin chemotactic receptor 1

      See identical proteins and their annotated locations for NP_031603.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC156630, BB666123, BC125641
      Consensus CDS
      CCDS20846.1
      UniProtKB/Swiss-Prot
      P30993
      Related
      ENSMUSP00000060003.5, ENSMUST00000050770.5
      Conserved Domains (1) summary
      pfam00001
      Location:54301
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      16246743..16259540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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