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    C1qbp complement component 1, q subcomponent binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12261, updated on 24-Feb-2019

    Summary

    Official Symbol
    C1qbpprovided by MGI
    Official Full Name
    complement component 1, q subcomponent binding proteinprovided by MGI
    Primary source
    MGI:MGI:1194505
    See related
    Ensembl:ENSMUSG00000018446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P32; HABP1; gC1qBP; AA407365; AA986492; D11Wsu182e
    Expression
    Broad expression in adrenal adult (RPKM 411.1), stomach adult (RPKM 150.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See C1qbp in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (70977846..70983026, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70791348..70796528, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene predicted gene 12322 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene Der1-like domain family, member 2 Neighboring gene MIS12 kinetochore complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    complement component C1q binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    complement component C1q binding ISO
    Inferred from Sequence Orthology
    more info
     
    hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    kininogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kininogen binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mature ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mature ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mature ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement component 1 Q subcomponent-binding protein, mitochondrial
    Names
    GC1q-R protein
    glycoprotein gC1qBP

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007573.2NP_031599.2  complement component 1 Q subcomponent-binding protein, mitochondrial

      See identical proteins and their annotated locations for NP_031599.2

      Status: VALIDATED

      Source sequence(s)
      AK010601, BY275303, CF381952
      Consensus CDS
      CCDS24970.1
      UniProtKB/TrEMBL
      Q8R5L1
      Related
      ENSMUSP00000077612.6, ENSMUST00000078528.6
      Conserved Domains (1) summary
      pfam02330
      Location:87270
      MAM33; Mitochondrial glycoprotein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      70977846..70983026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1086208..1091430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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