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    Bub3 BUB3 mitotic checkpoint protein [ Mus musculus (house mouse) ]

    Gene ID: 12237, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bub3provided by MGI
    Official Full Name
    BUB3 mitotic checkpoint proteinprovided by MGI
    Primary source
    MGI:MGI:1343463
    See related
    Ensembl:ENSMUSG00000066979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C78067; AU019800; AU021329; AU043350; AW146323
    Summary
    This gene encodes a component of the mitotic spindle assembly complex. The encoded protein is involved in the regulation of chromosome segregation during oocyte meiosis. Disruption of this gene results in the accumulation of mitotic errors and is lethal in the embryonic stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 62.1), limb E14.5 (RPKM 56.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bub3 in Genome Data Viewer
    Location:
    7 F3; 7 74.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (131560370..131571895)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (138703905..138715412)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene H6 homeobox 3 Neighboring gene H6 homeobox 2 Neighboring gene ribosomal protein L7a pseudogene Neighboring gene U1 small nuclear ribonucleoprotein 1C pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    bub1-bub3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic checkpoint complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitotic checkpoint protein BUB3
    Names
    WD repeat type I transmembrane protein A72.5
    budding uninhibited by benzimidazoles 3 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317350.1NP_001304279.1  mitotic checkpoint protein BUB3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC086790, CN699411
      Consensus CDS
      CCDS40160.1
      UniProtKB/Swiss-Prot
      Q9WVA3
      Related
      ENSMUSP00000146334.1, ENSMUST00000207442.1
      Conserved Domains (2) summary
      sd00039
      Location:1754
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:14296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_009774.4NP_033904.2  mitotic checkpoint protein BUB3

      See identical proteins and their annotated locations for NP_033904.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC159994, BC086790
      Consensus CDS
      CCDS40160.1
      UniProtKB/Swiss-Prot
      Q9WVA3
      Related
      ENSMUSP00000081547.5, ENSMUST00000084502.6
      Conserved Domains (2) summary
      sd00039
      Location:1754
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:14296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      131560370..131571895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507271.3XP_006507334.1  mitotic checkpoint protein BUB3 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:3165
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:2186
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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