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    Btrc beta-transducin repeat containing protein [ Mus musculus (house mouse) ]

    Gene ID: 12234, updated on 12-Feb-2019

    Summary

    Official Symbol
    Btrcprovided by MGI
    Official Full Name
    beta-transducin repeat containing proteinprovided by MGI
    Primary source
    MGI:MGI:1338871
    See related
    Ensembl:ENSMUSG00000025217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOS; FWD1; Fbw1a; Slimb; b-TrCP; beta-TrCP; Beta-Trcp1; SCF b-TRCP; E3RSIkappaB; E3RS-IkappaB
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E18 (RPKM 10.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Btrc in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (45363734..45533343)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45438224..45607833)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102640042 Neighboring gene predicted gene 28578 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 41856 Neighboring gene predicted gene, 19639 Neighboring gene polymerase (DNA directed), lambda

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4123, mKIAA4123

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylated amino acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box/WD repeat-containing protein 1A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037758.2NP_001032847.2  F-box/WD repeat-containing protein 1A isoform a

      See identical proteins and their annotated locations for NP_001032847.2

      Status: VALIDATED

      Source sequence(s)
      AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
      Consensus CDS
      CCDS29860.1
      UniProtKB/Swiss-Prot
      Q3ULA2
      Related
      ENSMUSP00000070728.5, ENSMUST00000065601.12
      Conserved Domains (5) summary
      COG2319
      Location:290586
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:303581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:139177
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:181228
      F-box-like; F-box-like
      sd00039
      Location:306341
      7WD40; WD40 repeat [structural motif]
    2. NM_001286465.1NP_001273394.1  F-box/WD repeat-containing protein 1A isoform a

      See identical proteins and their annotated locations for NP_001273394.1

      Status: VALIDATED

      Source sequence(s)
      AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
      Consensus CDS
      CCDS29860.1
      UniProtKB/Swiss-Prot
      Q3ULA2
      Conserved Domains (5) summary
      COG2319
      Location:290586
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:303581
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:139177
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:181228
      F-box-like; F-box-like
      sd00039
      Location:306341
      7WD40; WD40 repeat [structural motif]
    3. NM_001286466.1NP_001273395.1  F-box/WD repeat-containing protein 1A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
      UniProtKB/Swiss-Prot
      Q3ULA2
      Conserved Domains (3) summary
      COG2319
      Location:68364
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:81359
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:84119
      7WD40; WD40 repeat [structural motif]
    4. NM_001360120.1NP_001347049.1  F-box/WD repeat-containing protein 1A isoform d

      Status: VALIDATED

      Source sequence(s)
      AC123058, AC126454, BP768842
      Conserved Domains (4) summary
      cd00200
      Location:317595
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:320355
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:153191
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:195242
      F-box-like; F-box-like
    5. NM_001360122.1NP_001347051.1  F-box/WD repeat-containing protein 1A isoform e

      Status: VALIDATED

      Source sequence(s)
      AC123058, AC126454, BP768842
      Conserved Domains (4) summary
      cd00200
      Location:291569
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:294329
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:127165
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:169216
      F-box-like; F-box-like
    6. NM_001360124.1NP_001347053.1  F-box/WD repeat-containing protein 1A isoform f

      Status: VALIDATED

      Source sequence(s)
      AC123058, AC126454, BP768842
      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like; F-box-like
    7. NM_001360126.1NP_001347055.1  F-box/WD repeat-containing protein 1A isoform g

      Status: VALIDATED

      Source sequence(s)
      AC123058, AC126454, BP768842
      Conserved Domains (4) summary
      cd00200
      Location:281559
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:284319
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:117155
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:159206
      F-box-like; F-box-like
    8. NM_001360127.1NP_001347056.1  F-box/WD repeat-containing protein 1A isoform h

      Status: VALIDATED

      Source sequence(s)
      AC123058, AC126454, BP768842
      Conserved Domains (4) summary
      cd00200
      Location:277555
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:280315
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:113151
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:155202
      F-box-like; F-box-like
    9. NM_009771.3NP_033901.1  F-box/WD repeat-containing protein 1A isoform b

      See identical proteins and their annotated locations for NP_033901.1

      Status: VALIDATED

      Source sequence(s)
      AC126454, AK052317, AK145624, BP768842, BY070850, BY290279
      Consensus CDS
      CCDS38002.1
      UniProtKB/Swiss-Prot
      Q3ULA2
      Related
      ENSMUSP00000107567.2, ENSMUST00000111936.3
      Conserved Domains (5) summary
      COG2319
      Location:254550
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:267545
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:103141
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:145192
      F-box-like; F-box-like
      sd00039
      Location:270305
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      45363734..45533343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526607.3XP_006526670.2  F-box/WD repeat-containing protein 1A isoform X1

      Conserved Domains (4) summary
      cd00200
      Location:317595
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:320355
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:153191
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:195242
      F-box-like; F-box-like
    2. XM_011247122.2XP_011245424.1  F-box/WD repeat-containing protein 1A isoform X6

      Conserved Domains (4) summary
      cd00200
      Location:281559
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:284319
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:117155
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:159206
      F-box-like; F-box-like
    3. XM_006526610.3XP_006526673.2  F-box/WD repeat-containing protein 1A isoform X2

      Conserved Domains (4) summary
      cd00200
      Location:291569
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:294329
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:127165
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:169216
      F-box-like; F-box-like
    4. XM_006526608.2XP_006526671.1  F-box/WD repeat-containing protein 1A isoform X7

      Conserved Domains (4) summary
      cd00200
      Location:277555
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:280315
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:113151
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:155202
      F-box-like; F-box-like
    5. XM_006526612.2XP_006526675.1  F-box/WD repeat-containing protein 1A isoform X10

      Conserved Domains (5) summary
      COG2319
      Location:228524
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:241519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:77115
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:119166
      F-box-like; F-box-like
      sd00039
      Location:244279
      7WD40; WD40 repeat [structural motif]
    6. XM_017318046.1XP_017173535.1  F-box/WD repeat-containing protein 1A isoform X4

      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like; F-box-like
    7. XM_011247119.2XP_011245421.1  F-box/WD repeat-containing protein 1A isoform X3

      Conserved Domains (5) summary
      COG2319
      Location:274570
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:287565
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:123161
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:165212
      F-box-like; F-box-like
      sd00039
      Location:290325
      7WD40; WD40 repeat [structural motif]
    8. XM_006526614.3XP_006526677.2  F-box/WD repeat-containing protein 1A isoform X8

      Conserved Domains (5) summary
      COG2319
      Location:248544
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:261539
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:97135
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:139186
      F-box-like; F-box-like
      sd00039
      Location:264299
      7WD40; WD40 repeat [structural motif]
    9. XM_011247123.2XP_011245425.1  F-box/WD repeat-containing protein 1A isoform X9

      Conserved Domains (5) summary
      COG2319
      Location:242538
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:255533
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:91129
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:133180
      F-box-like; F-box-like
      sd00039
      Location:258293
      7WD40; WD40 repeat [structural motif]
    10. XM_006526613.2XP_006526676.1  F-box/WD repeat-containing protein 1A isoform X11

      Conserved Domains (5) summary
      COG2319
      Location:224520
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:237515
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:73111
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:115162
      F-box-like; F-box-like
      sd00039
      Location:240275
      7WD40; WD40 repeat [structural motif]
    11. XM_011247127.2XP_011245429.1  F-box/WD repeat-containing protein 1A isoform X12

      See identical proteins and their annotated locations for XP_011245429.1

      UniProtKB/TrEMBL
      A0A286YDT6
      Conserved Domains (5) summary
      COG2319
      Location:191487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like; F-box-like
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
    12. XM_011247120.2XP_011245422.1  F-box/WD repeat-containing protein 1A isoform X4

      See identical proteins and their annotated locations for XP_011245422.1

      Conserved Domains (4) summary
      cd00200
      Location:285563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:288323
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:121159
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:163210
      F-box-like; F-box-like
    13. XM_011247121.2XP_011245423.1  F-box/WD repeat-containing protein 1A isoform X5

      Conserved Domains (5) summary
      COG2319
      Location:269565
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:282560
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:118156
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:160207
      F-box-like; F-box-like
      sd00039
      Location:285320
      7WD40; WD40 repeat [structural motif]
    14. XM_006526615.2XP_006526678.1  F-box/WD repeat-containing protein 1A isoform X12

      See identical proteins and their annotated locations for XP_006526678.1

      UniProtKB/TrEMBL
      A0A286YDT6
      Related
      ENSMUSP00000153562.1, ENSMUST00000224478.1
      Conserved Domains (5) summary
      COG2319
      Location:191487
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:204482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:4078
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:82129
      F-box-like; F-box-like
      sd00039
      Location:207242
      7WD40; WD40 repeat [structural motif]
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