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    Birc6 baculoviral IAP repeat-containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 12211, updated on 31-Jan-2019

    Summary

    Official Symbol
    Birc6provided by MGI
    Official Full Name
    baculoviral IAP repeat-containing 6provided by MGI
    Primary source
    MGI:MGI:1276108
    See related
    Ensembl:ENSMUSG00000024073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bruce; AA501170; mKIAA1289; A430032G04Rik; A430040A19Rik; D630005A10Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.8), spleen adult (RPKM 8.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Birc6 in Genome Data Viewer
    Location:
    17; 17 E2
    Exon count:
    75
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (74528250..74703356)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (74927635..75103113)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 4 Neighboring gene predicted gene, 31645 Neighboring gene tetratricopeptide repeat domain 27 Neighboring gene predicted gene, 31759 Neighboring gene predicted gene, 31818

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IC
    Inferred by Curator
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    spongiotrophoblast layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 6
    Names
    BIR repeat-containing ubiquitin-conjugating enzyme
    RING-type E3 ubiquitin transferase BIRC6
    apollon
    baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme
    baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6
    ubiquitin-conjugating BIR domain enzyme apollon
    NP_031592.3
    XP_006523581.1
    XP_006523582.1
    XP_006523583.1
    XP_006523584.1
    XP_006523585.1
    XP_006523586.1
    XP_006523587.1
    XP_006523589.1
    XP_006523590.1
    XP_006523591.1
    XP_006523592.1
    XP_011244559.1
    XP_017172705.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007566.3NP_031592.3  baculoviral IAP repeat-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      AC098726, AC154442, AK041241, AK042247, AK045446, AK052612, AK134254, AK173143, BG695066, CN536181, CN707067, CO424370, DV651019
      Consensus CDS
      CCDS37693.2
      UniProtKB/Swiss-Prot
      O88738
      UniProtKB/TrEMBL
      Q3UYZ6
      Related
      ENSMUSP00000136329.1, ENSMUST00000180037.7
      Conserved Domains (3) summary
      cd00022
      Location:290363
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46134751
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:34803632
      DUF3643; Protein of unknown function (DUF3643)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      74528250..74703356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317216.1XP_017172705.1  baculoviral IAP repeat-containing protein 6 isoform X13

    2. XM_006523529.3XP_006523592.1  baculoviral IAP repeat-containing protein 6 isoform X12

      Conserved Domains (1) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    3. XM_011246257.2XP_011244559.1  baculoviral IAP repeat-containing protein 6 isoform X11

      Conserved Domains (2) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      pfam12356
      Location:35603712
      DUF3643; Protein of unknown function (DUF3643)
    4. XM_006523521.2XP_006523584.1  baculoviral IAP repeat-containing protein 6 isoform X4

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46874825
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35543706
      DUF3643; Protein of unknown function (DUF3643)
    5. XM_006523526.3XP_006523589.1  baculoviral IAP repeat-containing protein 6 isoform X8

      Related
      ENSMUSP00000138732.1, ENSMUST00000182944.7
      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46664804
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35333685
      DUF3643; Protein of unknown function (DUF3643)
    6. XM_006523518.2XP_006523581.1  baculoviral IAP repeat-containing protein 6 isoform X1

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46934831
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35603712
      DUF3643; Protein of unknown function (DUF3643)
    7. XM_006523520.2XP_006523583.1  baculoviral IAP repeat-containing protein 6 isoform X3

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46874825
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35543706
      DUF3643; Protein of unknown function (DUF3643)
    8. XM_006523522.2XP_006523585.1  baculoviral IAP repeat-containing protein 6 isoform X5

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46844822
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35513703
      DUF3643; Protein of unknown function (DUF3643)
    9. XM_006523524.2XP_006523587.1  baculoviral IAP repeat-containing protein 6 isoform X7

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46784816
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35453697
      DUF3643; Protein of unknown function (DUF3643)
    10. XM_006523527.2XP_006523590.1  baculoviral IAP repeat-containing protein 6 isoform X9

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46604798
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35273679
      DUF3643; Protein of unknown function (DUF3643)
    11. XM_006523519.2XP_006523582.1  baculoviral IAP repeat-containing protein 6 isoform X2

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46894827
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35563708
      DUF3643; Protein of unknown function (DUF3643)
    12. XM_006523523.3XP_006523586.1  baculoviral IAP repeat-containing protein 6 isoform X6

      UniProtKB/TrEMBL
      A0A1S6GWH6
      Related
      ENSMUSP00000138333.1, ENSMUST00000182597.7
      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46794817
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35463698
      BIRC6; Baculoviral IAP repeat-containing protein 6
    13. XM_006523528.3XP_006523591.1  baculoviral IAP repeat-containing protein 6 isoform X10

      Conserved Domains (3) summary
      cd00022
      Location:347420
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:46494787
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:35163668
      DUF3643; Protein of unknown function (DUF3643)

    RNA

    1. XR_385268.3 RNA Sequence

    2. XR_385267.3 RNA Sequence

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