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    Zfp36l2 zinc finger protein 36, C3H type-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 12193, updated on 3-Jun-2018

    Summary

    Official Symbol
    Zfp36l2provided by MGI
    Official Full Name
    zinc finger protein 36, C3H type-like 2provided by MGI
    Primary source
    MGI:MGI:107945
    See related
    Ensembl:ENSMUSG00000045817 Vega:OTTMUSG00000020082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brf2; ERF2; Tis11d
    Expression
    Broad expression in colon adult (RPKM 134.5), ovary adult (RPKM 123.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See Zfp36l2 in Genome Data Viewer
    Location:
    17; 17 E4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (84183924..84187947, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (84583264..84587287, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 19696 Neighboring gene predicted gene, 41640 Neighboring gene predicted gene, 36279 Neighboring gene thyroid adenoma associated Neighboring gene predicted gene, 41642

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • TYROBP Causal Network, organism-specific biosystem (from WikiPathways)
      TYROBP Causal Network, organism-specific biosystemBased on Figure 6A from Zhang et al. Converted from the original human network to mouse. Gimap2 and Lgals9 (light gray) have no mouse ortholog.

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AU-rich element binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell differentiation in thymus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fibroblast growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mRNA decay activator protein ZFP36L2
    Names
    TPA-induced sequence 11d
    ZFP36-like 2
    butyrate response factor 2
    zinc finger protein 36, C3H1 type-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001806.2NP_001001806.1  mRNA decay activator protein ZFP36L2

      See identical proteins and their annotated locations for NP_001001806.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132455, BB656287
      Consensus CDS
      CCDS28998.1
      UniProtKB/Swiss-Prot
      P23949
      Related
      ENSMUSP00000050820.6, OTTMUSP00000021700, ENSMUST00000060366.6, OTTMUST00000047765
      Conserved Domains (2) summary
      pfam00642
      Location:156181
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:3133
      Tis11B_N; Tis11B like protein, N terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      84183924..84187947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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