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    Bop1 block of proliferation 1 [ Mus musculus (house mouse) ]

    Gene ID: 12181, updated on 12-Sep-2021

    Summary

    Official Symbol
    Bop1provided by MGI
    Official Full Name
    block of proliferation 1provided by MGI
    Primary source
    MGI:MGI:1334460
    See related
    Ensembl:ENSMUSG00000022557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erb; Erb1p; D18861; AU020183; AW146150; Kiaa0124; mKIAA0124
    Expression
    Ubiquitous expression in ovary adult (RPKM 54.9), thymus adult (RPKM 50.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Bop1 in Genome Data Viewer
    Location:
    15 D3; 15 35.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76337188..76361449, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76452988..76477249, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76283426..76307699, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase 5 Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene scleraxis Neighboring gene heat shock factor 1 Neighboring gene diacylglycerol O-acyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PeBoW complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of PeBoW complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosome biogenesis protein BOP1
    Names
    block of proliferation 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013481.2NP_038509.1  ribosome biogenesis protein BOP1

      See identical proteins and their annotated locations for NP_038509.1

      Status: VALIDATED

      Source sequence(s)
      AK079627, AV349722
      Consensus CDS
      CCDS27570.1
      UniProtKB/Swiss-Prot
      P97452
      Related
      ENSMUSP00000023217.10, ENSMUST00000023217.11
      Conserved Domains (4) summary
      COG2319
      Location:395732
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:394732
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08145
      Location:130388
      BOP1NT; BOP1NT (NUC169) domain
      sd00039
      Location:403441
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76337188..76361449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159096.1XP_036014989.1  ribosome biogenesis protein BOP1 isoform X1

      Conserved Domains (3) summary
      cd00200
      Location:233571
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:242280
      7WD40; WD40 repeat [structural motif]
      pfam08145
      Location:1227
      BOP1NT; BOP1NT (NUC169) domain
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