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    Bnip3l BCL2/adenovirus E1B interacting protein 3-like [ Mus musculus (house mouse) ]

    Gene ID: 12177, updated on 2-Nov-2024

    Summary

    Official Symbol
    Bnip3lprovided by MGI
    Official Full Name
    BCL2/adenovirus E1B interacting protein 3-likeprovided by MGI
    Primary source
    MGI:MGI:1332659
    See related
    Ensembl:ENSMUSG00000022051 AllianceGenome:MGI:1332659
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nix; Nip3L; D14Ertd719e
    Summary
    Enables identical protein binding activity. Involved in regulation of mitophagy and regulation of protein targeting to mitochondrion. Acts upstream of or within positive regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 35.8), liver E14.5 (RPKM 29.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bnip3l in Genome Data Viewer
    Location:
    14 D1; 14 34.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67222688..67246580, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66985238..67008877, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cold shock domain containing E1, RNA binding pseudogene Neighboring gene predicted gene, 24258 Neighboring gene STARR-positive B cell enhancer mm9_chr14:67627653-67627954 Neighboring gene protein phosphatase 2, regulatory subunit B, alpha Neighboring gene STARR-seq mESC enhancer starr_37004 Neighboring gene STARR-positive B cell enhancer ABC_E7328 Neighboring gene predicted gene, 52123

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lamin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein targeting to mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    Names
    BCL2/adenovirus E1B 19 kDa-interacting protein 3-like
    BCL2/adenovirus E1B 19kDa-interacting protein 3-like
    NIP3-like protein X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001422131.1NP_001409060.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165148
    2. NM_001422132.1NP_001409061.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165148
    3. NM_001422133.1NP_001409062.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165148
    4. NM_001422134.1NP_001409063.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165148
    5. NM_009761.4NP_033891.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

      See identical proteins and their annotated locations for NP_033891.1

      Status: VALIDATED

      Source sequence(s)
      AC165148
      Consensus CDS
      CCDS27227.1
      UniProtKB/Swiss-Prot
      Q545J6, Q9Z2F7
      UniProtKB/TrEMBL
      Q3TEW0
      Related
      ENSMUSP00000022634.9, ENSMUST00000022634.9
      Conserved Domains (1) summary
      pfam06553
      Location:22217
      BNIP3; BNIP3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      67222688..67246580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158414.1XP_036014307.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1

      Conserved Domains (1) summary
      pfam06553
      Location:101277
      BNIP3