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    Bnip3 BCL2/adenovirus E1B interacting protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 12176, updated on 19-Feb-2019

    Summary

    Official Symbol
    Bnip3provided by MGI
    Official Full Name
    BCL2/adenovirus E1B interacting protein 3provided by MGI
    Primary source
    MGI:MGI:109326
    See related
    Ensembl:ENSMUSG00000078566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nip3
    Expression
    Broad expression in liver E18 (RPKM 92.5), placenta adult (RPKM 48.1) and 20 other tissues See more
    Orthologs

    Genomic context

    See Bnip3 in Genome Data Viewer
    Location:
    7; 7 F4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (138890836..138909506, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (146082519..146101189, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 Neighboring gene protein phosphatase 2, regulatory subunit B, delta Neighboring gene gamma-glutamyl hydrolase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene janus kinase and microtubule interacting protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cobalt ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    granzyme-mediated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of necrotic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
    Names
    BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3
    BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3
    BCL2/adenovirus E1B interacting protein 1, NIP3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009760.4NP_033890.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

      See identical proteins and their annotated locations for NP_033890.1

      Status: VALIDATED

      Source sequence(s)
      AC140248
      Consensus CDS
      CCDS40168.1
      UniProtKB/Swiss-Prot
      O55003
      Related
      ENSMUSP00000101718.1, ENSMUST00000106112.1
      Conserved Domains (1) summary
      pfam06553
      Location:2185
      BNIP3; BNIP3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      138890836..138909506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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