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    Bmpr1a bone morphogenetic protein receptor, type 1A [ Mus musculus (house mouse) ]

    Gene ID: 12166, updated on 19-Mar-2019

    Summary

    Official Symbol
    Bmpr1aprovided by MGI
    Official Full Name
    bone morphogenetic protein receptor, type 1Aprovided by MGI
    Primary source
    MGI:MGI:1338938
    See related
    Ensembl:ENSMUSG00000021796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALK3; Bmpr; SKR5; ALK-3; BMPR-1A; BMPR-IA; AU045487; 1110037I22Rik
    Expression
    Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues See more
    Orthologs

    Genomic context

    See Bmpr1a in Genome Data Viewer
    Location:
    14 B; 14 20.81 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (34411068..34503461, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (35224254..35315732, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene synuclein, gamma Neighboring gene multimerin 2 Neighboring gene RIKEN cDNA 9230112D13 gene Neighboring gene LIM domain binding 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    BMP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transforming growth factor beta-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    BMP signaling pathway involved in heart development IC
    Inferred by Curator
    more info
    PubMed 
    Mullerian duct regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac conduction system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibrous ring of heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lateral mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesendoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitral valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural plate mediolateral regionalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural plate pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paraxial mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    paraxial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paraxial mesoderm structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vascular smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular senescence IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT regulation of endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of lateral mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT regulation of neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT regulation of neural crest cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    tricuspid valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular compact myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular trabecula myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    bone morphogenetic protein receptor type-1A
    Names
    BMP type-1A receptor
    BMP-2/BMP-4 receptor
    activin receptor-like kinase 3
    serine/threonine-protein kinase receptor R5
    NP_033888.2
    XP_006518532.1
    XP_006518533.1
    XP_017171295.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009758.4NP_033888.2  bone morphogenetic protein receptor type-1A precursor

      See identical proteins and their annotated locations for NP_033888.2

      Status: VALIDATED

      Source sequence(s)
      AC160930, AC166105
      Consensus CDS
      CCDS26938.1
      UniProtKB/Swiss-Prot
      P36895
      UniProtKB/TrEMBL
      Q53Z43
      Related
      ENSMUSP00000035900.8, ENSMUST00000049005.14
      Conserved Domains (3) summary
      smart00221
      Location:234521
      STYKc; Protein kinase; unclassified specificity
      cd14220
      Location:238524
      STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
      pfam01064
      Location:59138
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      34411068..34503461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518470.3XP_006518533.1  bone morphogenetic protein receptor type-1A isoform X1

      See identical proteins and their annotated locations for XP_006518533.1

      UniProtKB/Swiss-Prot
      P36895
      UniProtKB/TrEMBL
      Q53Z43
      Conserved Domains (3) summary
      smart00221
      Location:234521
      STYKc; Protein kinase; unclassified specificity
      cd14220
      Location:238524
      STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
      pfam01064
      Location:59138
      Activin_recp; Activin types I and II receptor domain
    2. XM_006518469.3XP_006518532.1  bone morphogenetic protein receptor type-1A isoform X1

      See identical proteins and their annotated locations for XP_006518532.1

      UniProtKB/Swiss-Prot
      P36895
      UniProtKB/TrEMBL
      Q53Z43
      Related
      ENSMUSP00000131984.1, ENSMUST00000165280.7
      Conserved Domains (3) summary
      smart00221
      Location:234521
      STYKc; Protein kinase; unclassified specificity
      cd14220
      Location:238524
      STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
      pfam01064
      Location:59138
      Activin_recp; Activin types I and II receptor domain
    3. XM_017315806.1XP_017171295.1  bone morphogenetic protein receptor type-1A isoform X1

      UniProtKB/Swiss-Prot
      P36895
      UniProtKB/TrEMBL
      Q53Z43
      Conserved Domains (3) summary
      smart00221
      Location:234521
      STYKc; Protein kinase; unclassified specificity
      cd14220
      Location:238524
      STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
      pfam01064
      Location:59138
      Activin_recp; Activin types I and II receptor domain
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