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    Bmp15 bone morphogenetic protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 12155, updated on 5-Mar-2024


    Official Symbol
    Bmp15provided by MGI
    Official Full Name
    bone morphogenetic protein 15provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000023279 AllianceGenome:MGI:1316745
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmp-15; GDF-9B
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Female mice lacking a functional copy of this gene exhibit impaired fertility. [provided by RefSeq, Aug 2016]
    Biased expression in ovary adult (RPKM 2.8) and kidney adult (RPKM 0.2) See more
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    Genomic context

    See Bmp15 in Genome Data Viewer
    X A1.1; X 2.81 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6226108..6232778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6314054..6320724, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33733 Neighboring gene predicted gene, 46685 Neighboring gene STARR-seq mESC enhancer starr_46655 Neighboring gene RIKEN cDNA 5430428K19 gene Neighboring gene shroom family member 4 Neighboring gene STARR-seq mESC enhancer starr_46656 Neighboring gene STARR-seq mESC enhancer starr_46657 Neighboring gene STARR-seq mESC enhancer starr_46658 Neighboring gene diacylglycerol kinase kappa

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    bone morphogenetic protein 15
    growth/differentiation factor 9B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009757.5NP_033887.1  bone morphogenetic protein 15 preproprotein

      See identical proteins and their annotated locations for NP_033887.1

      Status: REVIEWED

      Source sequence(s)
      AK135882, AK139773, AU019682
      Consensus CDS
      Q3UT46, Q9Z0L4
      ENSMUSP00000024049.8, ENSMUST00000024049.8
      Conserved Domains (1) summary
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000086.8 Reference GRCm39 C57BL/6J

      6226108..6232778 complement
      GenBank, FASTA, Sequence Viewer (Graphics)