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    Bdnf brain derived neurotrophic factor [ Mus musculus (house mouse) ]

    Gene ID: 12064, updated on 15-Jul-2024

    Summary

    Official Symbol
    Bdnfprovided by MGI
    Official Full Name
    brain derived neurotrophic factorprovided by MGI
    Primary source
    MGI:MGI:88145
    See related
    Ensembl:ENSMUSG00000048482 AllianceGenome:MGI:88145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.4) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Bdnf in Genome Data Viewer
    Location:
    2 E3; 2 56.63 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (109505045..109557388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109674700..109727043)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene kinesin family member 18A Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05355 Neighboring gene STARR-seq mESC enhancer starr_05357 Neighboring gene STARR-seq mESC enhancer starr_05358 Neighboring gene brain-derived neurotrophic factor antisense RNA Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05359 Neighboring gene STARR-positive B cell enhancer ABC_E9200 Neighboring gene predicted gene, 54141

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nerve growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neurotrophin TRKB receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to acid chemical IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in conditioned place preference ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendrite extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glutamate secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mechanoreceptor differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of collateral sprouting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of collateral sprouting IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of retinal cell programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within taste bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ureteric bud development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    brain-derived neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048139.1NP_001041604.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057911
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106680.4, ENSMUST00000111051.10
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    2. NM_001048141.1NP_001041606.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041606.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057913
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106679.4, ENSMUST00000111050.10
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    3. NM_001048142.1NP_001041607.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001041607.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057914
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106674.3, ENSMUST00000111045.9
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    4. NM_001285416.1NP_001272345.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057910
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106676.3, ENSMUST00000111047.9
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    5. NM_001285417.1NP_001272346.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY231131
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106672.3, ENSMUST00000111043.9
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    6. NM_001285418.1NP_001272347.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057909
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106678.3, ENSMUST00000111049.9
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    7. NM_001285419.1NP_001272348.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY057912
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106675.3, ENSMUST00000111046.9
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    8. NM_001285420.1NP_001272349.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000135762.2, ENSMUST00000176893.8
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    9. NM_001285421.1NP_001272350.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    10. NM_001285422.1NP_001272351.1  brain-derived neurotrophic factor isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001272351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    11. NM_001316310.1NP_001303239.1  brain-derived neurotrophic factor isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding region, and uses a downstream translation start compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 encode the same protein.
      Source sequence(s)
      AL732477, AY231132
      Consensus CDS
      CCDS38194.1
      UniProtKB/Swiss-Prot
      A2AII2, P21237, Q8CCH9
      UniProtKB/TrEMBL
      Q541P3, Q8VHH4
      Related
      ENSMUSP00000106673.3, ENSMUST00000111044.3
      Conserved Domains (1) summary
      smart00140
      Location:135242
      NGF; Nerve growth factor (NGF or beta-NGF)
    12. NM_007540.4NP_031566.4  brain-derived neurotrophic factor isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AL732477, AY057908
      Consensus CDS
      CCDS38193.1
      UniProtKB/TrEMBL
      Q8VHH4
      Related
      ENSMUSP00000057989.6, ENSMUST00000053317.12
      Conserved Domains (1) summary
      smart00140
      Location:143250
      NGF; Nerve growth factor (NGF or beta-NGF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      109505045..109557388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)