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    Bcl2l1 BCL2-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 12048, updated on 14-Sep-2021

    Summary

    Official Symbol
    Bcl2l1provided by MGI
    Official Full Name
    BCL2-like 1provided by MGI
    Primary source
    MGI:MGI:88139
    See related
    Ensembl:ENSMUSG00000007659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcl; BclX; bcl-; Bcl(X; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
    Summary
    This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bcl2l1 in Genome Data Viewer
    Location:
    2 75.41 cM; 2 H1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152600652..152675723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152758732..152833803, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152606404..152657418, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene predicted gene, 32211 Neighboring gene TPX2, microtubule-associated Neighboring gene microRNA 5622 Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC99998, MGC113803

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables BH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process in bone marrow cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to alkaloid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fertilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cycloheximide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic vesicle recycling via endosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bcl-2-like protein 1
    Names
    B-cell leukemia/lymphoma x
    anti-apoptosis regulatory protein
    apoptosis regulator Bcl-X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289716.1NP_001276645.1  bcl-2-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
      Source sequence(s)
      AK146461, AL731857, BB735910, BY286706
      Consensus CDS
      CCDS16899.1
      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Related
      ENSMUSP00000105445.4, ENSMUST00000109820.5
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    2. NM_001289717.1NP_001276646.1  bcl-2-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
      Source sequence(s)
      AL731857
      Consensus CDS
      CCDS16899.1
      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    3. NM_001289739.1NP_001276668.1  bcl-2-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001276668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a different 3' structure resulting in a frameshift compared to variant 5. The resulting isoform (b, also known as Bcl-x gamma; PMID 9390687) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AK146461, AL731857, BY286706, U51277
      UniProtKB/TrEMBL
      O35843, Q5HZH3
      Conserved Domains (3) summary
      smart00265
      Location:127
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81188
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1188
      bcl-2; apoptosis regulator
    4. NM_001355053.1NP_001341982.1  bcl-2-like protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the shorter isoform (a, also known as Bcl-xL; PMID 7607090). Variants 1, 2, 3, and 5 all encode the same isoform (a).
      Source sequence(s)
      AL731857
      Consensus CDS
      CCDS16899.1
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    5. NM_009743.5NP_033873.3  bcl-2-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_033873.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
      Source sequence(s)
      AL731857, BB735910, BB856100, BC089016
      Consensus CDS
      CCDS16899.1
      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Related
      ENSMUSP00000007803.6, ENSMUST00000007803.12
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator

    RNA

    1. NR_149254.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' end compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5.
      Source sequence(s)
      AL731857

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152600652..152675723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498612.3XP_006498675.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006498675.1

      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    2. XM_011239260.3XP_011237562.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237562.1

      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator
    3. XM_006498611.5XP_006498674.1  bcl-2-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006498674.1

      UniProtKB/Swiss-Prot
      Q64373
      UniProtKB/TrEMBL
      Q5HZH3
      Conserved Domains (1) summary
      TIGR00865
      Location:1233
      bcl-2; apoptosis regulator

    RNA

    1. XR_374396.4 RNA Sequence

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