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    Bcl10 B cell leukemia/lymphoma 10 [ Mus musculus (house mouse) ]

    Gene ID: 12042, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bcl10provided by MGI
    Official Full Name
    B cell leukemia/lymphoma 10provided by MGI
    Primary source
    MGI:MGI:1337994
    See related
    Ensembl:ENSMUSG00000028191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLAP; ME10; cE10; CIPER; BCL-10; C81403; CARMEN; AI132454
    Expression
    Ubiquitous expression in large intestine adult (RPKM 10.2), bladder adult (RPKM 8.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bcl10 in Genome Data Viewer
    Location:
    3; 3 H2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (145924262..145934366)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145587342..145597247)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene cellular communication network factor 1 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene RIKEN cDNA 2410004B18 gene Neighboring gene predicted gene, 35352 Neighboring gene synapse defective 1, Rho GTPase, homolog 2 (C. elegans)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CARD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    T cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cellular defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of mature B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to food ISO
    Inferred from Sequence Orthology
    more info
     
    response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT thymocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    CBM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CBM complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    B-cell lymphoma/leukemia 10
    Names
    B-cell CLL/lymphoma 10
    CARD-containing molecule enhancing NF-kappa-B
    CARD-like apoptotic protein
    CED-3/ICH-1 prodomain homologous E10-like regulator
    cellular homolog of vCARMEN
    cellular-E10
    mammalian CARD-containing adapter molecule E10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009740.2NP_033870.1  B-cell lymphoma/leukemia 10

      See identical proteins and their annotated locations for NP_033870.1

      Status: VALIDATED

      Source sequence(s)
      AC123684, AK140179, AK150883, BU707261
      Consensus CDS
      CCDS17897.1
      UniProtKB/Swiss-Prot
      Q9Z0H7
      UniProtKB/TrEMBL
      B7ZWE5
      Related
      ENSMUSP00000029842.7, ENSMUST00000029842.8
      Conserved Domains (1) summary
      cd08810
      Location:17100
      CARD_BCL10; Caspase activation and recruitment domain of B-cell lymphoma 10

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      145924262..145934366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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