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    Bcat2 branched chain aminotransferase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 12036, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bcat2provided by MGI
    Official Full Name
    branched chain aminotransferase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1276534
    See related
    Ensembl:ENSMUSG00000030826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eca40; Bcat-2; Bcat(m)
    Expression
    Ubiquitous expression in adrenal adult (RPKM 36.2), subcutaneous fat pad adult (RPKM 34.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bcat2 in Genome Data Viewer
    Location:
    7 B3; 7 29.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (45569763..45589710)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52825733..52845078)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene predicted gene, 31479 Neighboring gene fibroblast growth factor 21 Neighboring gene fucosyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-isoleucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-leucine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-valine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    branched-chain-amino-acid transaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branched-chain-amino-acid transaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    branched-chain amino acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branched-chain amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    branched-chain amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    isoleucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    isoleucine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    isoleucine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leucine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    leucine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of hormone levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    valine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    branched-chain-amino-acid aminotransferase, mitochondrial
    NP_001229981.1
    NP_033867.1
    XP_006540650.1
    XP_017177442.1
    XP_017177443.1
    XP_017177444.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243052.1NP_001229981.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001229981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI327099, AK137049, AK160159
      Consensus CDS
      CCDS57549.1
      UniProtKB/TrEMBL
      O88374
      Related
      ENSMUSP00000148152.1, ENSMUST00000209204.1
      Conserved Domains (2) summary
      PRK13357
      Location:1353
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:48343
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    2. NM_009737.3NP_033867.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_033867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI327099, AK137049, BB630667, BY279029
      Consensus CDS
      CCDS21252.1
      UniProtKB/Swiss-Prot
      O35855
      UniProtKB/TrEMBL
      O88374, Q3ULU3
      Related
      ENSMUSP00000033098.7, ENSMUST00000033098.15
      Conserved Domains (2) summary
      PRK13357
      Location:41393
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:88383
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      45569763..45589710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321955.1XP_017177444.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X3

    2. XM_006540587.3XP_006540650.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00224
      Location:88234
      PLPDE_IV; PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate ...
    3. XM_017321953.1XP_017177442.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X1

    4. XM_017321954.1XP_017177443.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001243053.1: Suppressed sequence

      Description
      NM_001243053.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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