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    Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12013, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bach1provided by MGI
    Official Full Name
    BTB and CNC homology 1, basic leucine zipper transcription factor 1provided by MGI
    Primary source
    MGI:MGI:894680
    See related
    Ensembl:ENSMUSG00000025612 AllianceGenome:MGI:894680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6230421P05Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human BACH1 (BTB domain and CNC homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.9), large intestine adult (RPKM 9.3) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bach1 in Genome Data Viewer
    Location:
    16 C3.3; 16 49.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87495842..87530234)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87698954..87733346)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41401 Neighboring gene predicted gene, 22808 Neighboring gene predicted gene, 53917 Neighboring gene STARR-seq mESC enhancer starr_41404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87709451-87709604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87723887-87724040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87727532-87727781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87729167-87729320 Neighboring gene predicted gene, 32925 Neighboring gene predicted gene, 23994 Neighboring gene RIKEN cDNA 2810407A14 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription regulator protein BACH1
    Names
    BTB and CNC homolog 1
    BTB and CNC homology 1 transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007520.2NP_031546.1  transcription regulator protein BACH1

      See identical proteins and their annotated locations for NP_031546.1

      Status: VALIDATED

      Source sequence(s)
      AC164108, AK140903, AK141405
      Consensus CDS
      CCDS28293.1
      UniProtKB/Swiss-Prot
      P97302
      UniProtKB/TrEMBL
      Q3URL4, Q3US24
      Related
      ENSMUSP00000026703.6, ENSMUST00000026703.6
      Conserved Domains (2) summary
      cd14719
      Location:554624
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18277
      Location:7126
      BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87495842..87530234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248939.1XP_030104799.1  transcription regulator protein BACH1 isoform X2

      Conserved Domains (1) summary
      cd14719
      Location:272342
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    2. XM_006522879.4XP_006522942.1  transcription regulator protein BACH1 isoform X1

      See identical proteins and their annotated locations for XP_006522942.1

      UniProtKB/Swiss-Prot
      P97302
      UniProtKB/TrEMBL
      Q3URL4, Q3US24
      Conserved Domains (2) summary
      cd14719
      Location:554624
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18277
      Location:7126
      BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)