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    Axin1 axin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12005, updated on 31-Jan-2019

    Summary

    Official Symbol
    Axin1provided by MGI
    Official Full Name
    axin 1provided by MGI
    Primary source
    MGI:MGI:1096327
    See related
    Ensembl:ENSMUSG00000024182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Axin1 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.07 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (26131213..26195811)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26275631..26332756)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 8 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene predicted gene, 46600 Neighboring gene protein disulfide isomerase associated 2 Neighboring gene Rho GDP dissociation inhibitor (GDI) gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC132911

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    I-SMAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    axial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axial mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
     
    erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
     
    genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
     
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system process IMP
    Inferred from Mutant Phenotype
    more info
     
    nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    axin-1
    Names
    axis inhibition protein 1
    protein Fused

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159598.1NP_001153070.1  axin-1 isoform 1

      See identical proteins and their annotated locations for NP_001153070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC126438, AC140047
      Consensus CDS
      CCDS50042.1
      UniProtKB/TrEMBL
      Q14DJ8
      Related
      ENSMUSP00000132000.1, ENSMUST00000163421.7
      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:752827
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. NM_009733.2NP_033863.2  axin-1 isoform 2

      See identical proteins and their annotated locations for NP_033863.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant contains an alternate in-frame exon in the 3' coding region compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AA259709, AF009011, AW061082, BG803725, CJ060582
      Consensus CDS
      CCDS28547.2
      UniProtKB/Swiss-Prot
      O35625
      UniProtKB/TrEMBL
      E9QMJ8
      Related
      ENSMUSP00000073974.3, ENSMUST00000074370.9
      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:788863
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      26131213..26195811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523515.3XP_006523578.1  axin-1 isoform X1

      See identical proteins and their annotated locations for XP_006523578.1

      UniProtKB/TrEMBL
      E9QMJ8
      Conserved Domains (4) summary
      cd08707
      Location:94214
      RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
      cd11582
      Location:1685
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
      pfam00778
      Location:788863
      DIX; DIX domain
      pfam08833
      Location:468521
      Axin_b-cat_bind; Axin beta-catenin binding domain
    2. XM_006523516.2XP_006523579.1  axin-1 isoform X2

      Conserved Domains (2) summary
      pfam00778
      Location:428503
      DIX; DIX domain
      pfam08833
      Location:108161
      Axin_b-cat_bind; Axin beta-catenin binding domain
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