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    Auh AU RNA binding protein/enoyl-coenzyme A hydratase [ Mus musculus (house mouse) ]

    Gene ID: 11992, updated on 3-Feb-2019

    Summary

    Official Symbol
    Auhprovided by MGI
    Official Full Name
    AU RNA binding protein/enoyl-coenzyme A hydrataseprovided by MGI
    Primary source
    MGI:MGI:1338011
    See related
    Ensembl:ENSMUSG00000021460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77140; W91705
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.0), kidney adult (RPKM 9.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Auh in Genome Data Viewer
    Location:
    13; 13 B1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (52835107..52929705, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (52930479..53025046, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene spleen tyrosine kinase Neighboring gene expressed sequence BB123696 Neighboring gene predicted gene, 33315 Neighboring gene predicted gene, 40950 Neighboring gene nuclear factor, interleukin 3, regulated

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enoyl-CoA hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    itaconyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    methylglutaconyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    methylglutaconyl-CoA hydratase, mitochondrial
    Names
    AU-binding enoyl-CoA hydratase
    AU-specific RNA-binding enoyl-CoA hydratase
    itaconyl-CoA hydratase
    muAUH
    NP_057918.2
    XP_006516909.1
    XP_011242674.1
    XP_017170862.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016709.2NP_057918.2  methylglutaconyl-CoA hydratase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_057918.2

      Status: VALIDATED

      Source sequence(s)
      BB207692, BC049597, BY741014
      Consensus CDS
      CCDS26518.1
      UniProtKB/Swiss-Prot
      Q9JLZ3
      UniProtKB/TrEMBL
      A0A0R4J023
      Related
      ENSMUSP00000021913.9, ENSMUST00000021913.15
      Conserved Domains (1) summary
      cl23717
      Location:61314
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      52835107..52929705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244372.2XP_011242674.1  methylglutaconyl-CoA hydratase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl23717
      Location:1191
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    2. XM_017315373.1XP_017170862.1  methylglutaconyl-CoA hydratase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      E9QMT1
      Conserved Domains (1) summary
      cl23717
      Location:61114
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    3. XM_006516846.3XP_006516909.1  methylglutaconyl-CoA hydratase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      E9QMT1
      Related
      ENSMUSP00000105658.3, ENSMUST00000110031.3
      Conserved Domains (1) summary
      cl23717
      Location:61114
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RNA

    1. XR_382231.3 RNA Sequence

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