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    Atrn attractin [ Mus musculus (house mouse) ]

    Gene ID: 11990, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atrnprovided by MGI
    Official Full Name
    attractinprovided by MGI
    Primary source
    MGI:MGI:1341628
    See related
    Ensembl:ENSMUSG00000027312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mg; Mgc; Mgca; AW558010
    Summary
    This gene encodes a widely expressed transmembrane glycoprotein that plays important roles in diverse physiological processes such as regulation of hair pigmentation, monocyte-T cell interaction and control of energy homeostasis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the mahogany mouse phenotype of dark brown or black coat on a normally agouti background. Mice with loss-of-function mutations in this gene exhibit black coat color, tremor, adiposity, higher basal metabolic rate, juvenile-onset hypomyelination and age-dependent spongiform neurodegeneration of the central nervous system. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in bladder adult (RPKM 35.4), cortex adult (RPKM 13.3) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atrn in Genome Data Viewer
    Location:
    2 F1; 2 63.26 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130734363..130872249)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130906430..131030333)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (130732232..130856065)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 9 Neighboring gene Ppp1r14c pseudogene Neighboring gene RIKEN cDNA A730017L22 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 pseudogene Neighboring gene high mobility group box 1 pseudogene Neighboring gene predicted gene, 30286 Neighboring gene microRNA 6973b Neighboring gene predicted gene, 39937 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    attractin
    Names
    protein mahogany

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009730.3NP_033860.2  attractin preproprotein

      See identical proteins and their annotated locations for NP_033860.2

      Status: REVIEWED

      Source sequence(s)
      AL833771, AW124828, BE650220, BE953944, BY761276, CB519923, CB520374, CF745736, CN461550
      Consensus CDS
      CCDS16751.1
      UniProtKB/Swiss-Prot
      Q9WU60
      Related
      ENSMUSP00000028781.9, ENSMUST00000028781.9
      Conserved Domains (7) summary
      cd00041
      Location:131246
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:10611106
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:500549
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:339378
      Kelch_1; Kelch motif
      pfam01437
      Location:931982
      PSI; Plexin repeat
      pfam13854
      Location:391427
      Kelch_5; Kelch motif
      cl02432
      Location:787919
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130734363..130872249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498606.5XP_006498669.1  attractin isoform X2

      Conserved Domains (7) summary
      smart00423
      Location:683729
      PSI; domain found in Plexins, Semaphorins and Integrins
      PHA03098
      Location:363527
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:168283
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:10981143
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:537586
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:9681019
      PSI; Plexin repeat
      cl02432
      Location:824956
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    2. XM_011239259.2XP_011237561.1  attractin isoform X1

      Conserved Domains (7) summary
      smart00423
      Location:533579
      PSI; domain found in Plexins, Semaphorins and Integrins
      PHA03098
      Location:213377
      PHA03098; kelch-like protein; Provisional
      cd00041
      Location:25133
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:948993
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:387436
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:818869
      PSI; Plexin repeat
      cl02432
      Location:674806
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
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