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    Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C [ Mus musculus (house mouse) ]

    Gene ID: 11984, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atp6v0cprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit Cprovided by MGI
    Primary source
    MGI:MGI:88116
    See related
    Ensembl:ENSMUSG00000024121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1
    Expression
    Ubiquitous expression in kidney adult (RPKM 768.5), adrenal adult (RPKM 629.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp6v0c in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24163866..24169429, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24300833..24306374, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene predicted gene, 33409 Neighboring gene amidohydrolase domain containing 2 Neighboring gene TBC1 domain family, member 24 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    proton-exporting ATPase activity, phosphorylative mechanism ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal lumen acidification TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    vacuolar acidification TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     
    proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar proton-transporting V-type ATPase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase 16 kDa proteolipid subunit
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa
    ATPase, H+ transporting, lysosomal 16kD, V0 subunit C
    ATPase, H+ transporting, lysosomal 2
    H(+)-ATPase (mvp)
    V-ATPase 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit
    NP_033859.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361531.1NP_001348460.1  V-type proton ATPase 16 kDa proteolipid subunit isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BP769833, BY140472, CT010502
      Conserved Domains (2) summary
      TIGR01100
      Location:72177
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      pfam00137
      Location:152211
      ATP-synt_C; ATP synthase subunit C
    2. NM_001361532.1NP_001348461.1  V-type proton ATPase 16 kDa proteolipid subunit isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      CT010502
      Conserved Domains (2) summary
      TIGR01100
      Location:13118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      pfam00137
      Location:93152
      ATP-synt_C; ATP synthase subunit C
    3. NM_001361533.1NP_001348462.1  V-type proton ATPase 16 kDa proteolipid subunit isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BY140472, CT010502
      Conserved Domains (2) summary
      pfam00137
      Location:66125
      ATP-synt_C; ATP synthase subunit C
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    4. NM_001361534.1NP_001348463.1  V-type proton ATPase 16 kDa proteolipid subunit isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      CT010502
      Conserved Domains (2) summary
      pfam00137
      Location:66125
      ATP-synt_C; ATP synthase subunit C
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    5. NM_001361535.1NP_001348464.1  V-type proton ATPase 16 kDa proteolipid subunit isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BB873227, CT010502
      Conserved Domains (2) summary
      pfam00137
      Location:66125
      ATP-synt_C; ATP synthase subunit C
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    6. NM_009729.4NP_033859.1  V-type proton ATPase 16 kDa proteolipid subunit isoform b

      See identical proteins and their annotated locations for NP_033859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK002570, BC050939, BY245103
      Consensus CDS
      CCDS28476.1
      UniProtKB/Swiss-Prot
      P63082
      UniProtKB/TrEMBL
      A3KML5
      Related
      ENSMUSP00000024932.5, ENSMUST00000024932.11
      Conserved Domains (2) summary
      TIGR01100
      Location:13118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      pfam00137
      Location:93152
      ATP-synt_C; ATP synthase subunit C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      24163866..24169429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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