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    Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C [ Mus musculus (house mouse) ]

    Gene ID: 11984, updated on 26-Sep-2022

    Summary

    Official Symbol
    Atp6v0cprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit Cprovided by MGI
    Primary source
    MGI:MGI:88116
    See related
    Ensembl:ENSMUSG00000024121 AllianceGenome:MGI:88116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1
    Summary
    Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of autophagic cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within lysosomal lumen acidification. Predicted to be located in Golgi apparatus; lysosome; and synaptic vesicle. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 768.5), adrenal adult (RPKM 629.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp6v0c in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24382839..24388652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24163865..24169678, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene predicted gene, 33409 Neighboring gene amidohydrolase domain containing 2 Neighboring gene TBC1 domain family, member 24 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables P-type proton-exporting transporter activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proton-transporting V-type ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proton-transporting V-type ATPase, V0 domain TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transmembrane transporter complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    V-type proton ATPase 16 kDa proteolipid subunit c
    Names
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa
    ATPase, H+ transporting, lysosomal 16kD, V0 subunit C
    ATPase, H+ transporting, lysosomal 2
    H(+)-ATPase (mvp)
    V-ATPase 16 kDa proteolipid subunit
    V-ATPase 16 kDa proteolipid subunit c
    V-type proton ATPase 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit
    vacuolar proton pump 16 kDa proteolipid subunit c
    NP_001348460.1
    NP_001348461.1
    NP_001348462.1
    NP_001348463.1
    NP_001348464.1
    NP_033859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361531.1NP_001348460.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BP769833, BY140472, CT010502
      Conserved Domains (2) summary
      TIGR01100
      Location:72177
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      pfam00137
      Location:152211
      ATP-synt_C; ATP synthase subunit C
    2. NM_001361532.1NP_001348461.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      CT010502
      Consensus CDS
      CCDS28476.1
      UniProtKB/Swiss-Prot
      Q3TD69
      UniProtKB/TrEMBL
      A0A8C6GFA8, Q5XK06
      Related
      ENSMUSP00000111059.2, ENSMUST00000098862.9
      Conserved Domains (2) summary
      TIGR01100
      Location:13118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    3. NM_001361533.1NP_001348462.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BY140472, CT010502
      Conserved Domains (2) summary
      cd18176
      Location:59126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    4. NM_001361534.1NP_001348463.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      CT010502
      Conserved Domains (2) summary
      cd18176
      Location:59126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    5. NM_001361535.1NP_001348464.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
      Source sequence(s)
      BB873227, CT010502
      Conserved Domains (2) summary
      cd18176
      Location:59126
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:191
      ATP-synt_C; ATP synthase subunit C
    6. NM_009729.4NP_033859.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

      See identical proteins and their annotated locations for NP_033859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AK002570, BC050939, BY245103
      Consensus CDS
      CCDS28476.1
      UniProtKB/Swiss-Prot
      P63082, Q3TD69
      UniProtKB/TrEMBL
      A0A8C6GFA8, A3KML5, Q5XK06
      Related
      ENSMUSP00000024932.6, ENSMUST00000024932.12
      Conserved Domains (2) summary
      TIGR01100
      Location:13118
      V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
      cd18176
      Location:86153
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24382839..24388652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)