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    Atp9a ATPase, class II, type 9A [ Mus musculus (house mouse) ]

    Gene ID: 11981, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atp9aprovided by MGI
    Official Full Name
    ATPase, class II, type 9Aprovided by MGI
    Primary source
    MGI:MGI:1330826
    See related
    Ensembl:ENSMUSG00000027546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IIa
    Expression
    Ubiquitous expression in colon adult (RPKM 66.0), CNS E18 (RPKM 56.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp9a in Genome Data Viewer
    Location:
    2; 2 H3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168476358..168584290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168634438..168742370, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (168459938..168567300, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33413 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 Neighboring gene microRNA 7004 Neighboring gene VISTA enhancer mm1375 Neighboring gene spalt like transcription factor 4 Neighboring gene predicted gene 14261 Neighboring gene predicted gene, 25214

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0611

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable phospholipid-transporting ATPase IIA
    Names
    ATPase 9A, class II
    ATPase 9A, p type
    ATPase, class 2
    NP_001276374.1
    NP_001276375.1
    NP_001341906.1
    NP_001341907.1
    NP_056546.2
    XP_006498666.1
    XP_017170555.1
    XP_017170556.1
    XP_030102742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289445.1NP_001276374.1  probable phospholipid-transporting ATPase IIA isoform 2

      See identical proteins and their annotated locations for NP_001276374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK082271, AL844575, AL929248, BC094551, BE989200, BY123191
      Consensus CDS
      CCDS71202.1
      UniProtKB/TrEMBL
      Q505G9, Q8C288, Q8C4G3
      Related
      ENSMUSP00000104804.3, ENSMUST00000109175.9
      Conserved Domains (2) summary
      cd07541
      Location:39951
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      cl26237
      Location:449557
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_001289446.1NP_001276375.1  probable phospholipid-transporting ATPase IIA isoform 3

      See identical proteins and their annotated locations for NP_001276375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK082271, AL844575, BE989200, BY240030, BY293759
      Consensus CDS
      CCDS71203.1
      UniProtKB/TrEMBL
      Q8C4G3
      Related
      ENSMUSP00000104806.2, ENSMUST00000109177.8
      Conserved Domains (2) summary
      cd07541
      Location:37949
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      cl26237
      Location:447555
      Cation_ATPase; Cation transport ATPase (P-type)
    3. NM_001354977.1NP_001341906.1  probable phospholipid-transporting ATPase IIA isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844575, AL929248
      Conserved Domains (2) summary
      cd07541
      Location:33945
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:443551
      Cation_ATPase; Cation transport ATPase (P-type)
    4. NM_001354978.1NP_001341907.1  probable phospholipid-transporting ATPase IIA precursor

      Status: VALIDATED

      Source sequence(s)
      AL844575, AL929248
      Conserved Domains (2) summary
      cd07541
      Location:1871
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:369477
      Cation_ATPase; Cation transport ATPase (P-type)
    5. NM_015731.3NP_056546.2  probable phospholipid-transporting ATPase IIA isoform 1

      See identical proteins and their annotated locations for NP_056546.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL844575, AL929248
      Consensus CDS
      CCDS38345.1
      UniProtKB/Swiss-Prot
      O70228
      Related
      ENSMUSP00000029060.5, ENSMUST00000029060.11
      Conserved Domains (6) summary
      cd01427
      Location:652802
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01652
      Location:531045
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:109337
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:499573
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:40104
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8111039
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168476358..168584290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315066.1XP_017170555.1  probable phospholipid-transporting ATPase IIA isoform X2

      Conserved Domains (2) summary
      cd07541
      Location:1871
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:369477
      Cation_ATPase; Cation transport ATPase (P-type)
    2. XM_030246882.1XP_030102742.1  probable phospholipid-transporting ATPase IIA isoform X2

      Conserved Domains (2) summary
      cd07541
      Location:1871
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:369477
      Cation_ATPase; Cation transport ATPase (P-type)
    3. XM_006498603.1XP_006498666.1  probable phospholipid-transporting ATPase IIA isoform X1

      Conserved Domains (2) summary
      cd07541
      Location:34946
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:444552
      Cation_ATPase; Cation transport ATPase (P-type)
    4. XM_017315067.1XP_017170556.1  probable phospholipid-transporting ATPase IIA isoform X3

      Conserved Domains (2) summary
      pfam13246
      Location:14122
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:73516
      HAD_like; Haloacid Dehalogenase-like Hydrolases
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