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    Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 [ Mus musculus (house mouse) ]

    Gene ID: 11966, updated on 3-Feb-2019

    Summary

    Official Symbol
    Atp6v1b2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit B2provided by MGI
    Primary source
    MGI:MGI:109618
    See related
    Ensembl:ENSMUSG00000006273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HO57; Atp6b2; R74844; AI194269; AI790362
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 121.3), cortex adult (RPKM 113.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp6v1b2 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (69088736..69113718)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (71612635..71637617)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32997 Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene solute carrier family 18 (vesicular monoamine), member 1 Neighboring gene leucine zipper, putative tumor suppressor 1 Neighboring gene predicted gene, 39187 Neighboring gene predicted gene, 39188

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath HDA PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    V-type proton ATPase subunit B, brain isoform
    Names
    ATPase, H+ transporting, V1 subunit B, isoform 2
    ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2
    ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B, isoform 2
    V-ATPase subunit B 2
    endomembrane proton pump 58 kDa subunit
    lysosomal 56/58kDa
    vacuolar proton pump subunit B 2
    NP_031535.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007509.3NP_031535.2  V-type proton ATPase subunit B, brain isoform

      See identical proteins and their annotated locations for NP_031535.2

      Status: VALIDATED

      Source sequence(s)
      AK151200, AK197153, BC046302
      Consensus CDS
      CCDS40358.1
      UniProtKB/Swiss-Prot
      P62814
      Related
      ENSMUSP00000006435.7, ENSMUST00000006435.7
      Conserved Domains (4) summary
      cd01135
      Location:118401
      V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
      TIGR01040
      Location:46509
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
      pfam00306
      Location:417510
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:50116
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      69088736..69113718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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