Format

Send to:

Choose Destination
    • Showing Current items.

    Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A [ Mus musculus (house mouse) ]

    Gene ID: 11964, updated on 8-Jul-2021

    Summary

    Official Symbol
    Atp6v1aprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit Aprovided by MGI
    Primary source
    MGI:MGI:1201780
    See related
    Ensembl:ENSMUSG00000052459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V; VA; Atp; VA68; VPP2; Atp6a1; Atp6a2; AI647066; Atp6v1a1
    Expression
    Broad expression in cerebellum adult (RPKM 59.0), frontal lobe adult (RPKM 52.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atp6v1a in Genome Data Viewer
    Location:
    16; 16 B4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43905765..43960064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44085402..44139702, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (44085517..44139132, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46552 Neighboring gene GRAM domain containing 1C Neighboring gene microRNA 3470b Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene upstream transcription factor family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase catalytic subunit A
    Names
    70-kDa subunit
    ATPase, H+ transporting, V1 subunit A
    ATPase, H+ transporting, V1 subunit A1
    ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa
    ATPase, H+ transporting, lysosomal 70kD, V1 subunit A
    V-ATPase 69 kDa subunit
    V-ATPase subunit A
    lysosomal 70kDa
    vacuolar proton pump subunit alpha
    NP_001345132.1
    NP_001345133.1
    NP_031534.2
    XP_006521784.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358203.1NP_001345132.1  V-type proton ATPase catalytic subunit A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Consensus CDS
      CCDS28182.1
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    2. NM_001358204.1NP_001345133.1  V-type proton ATPase catalytic subunit A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Consensus CDS
      CCDS28182.1
      Related
      ENSMUSP00000066886.7, ENSMUST00000063661.13
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    3. NM_007508.6NP_031534.2  V-type proton ATPase catalytic subunit A

      See identical proteins and their annotated locations for NP_031534.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Consensus CDS
      CCDS28182.1
      UniProtKB/Swiss-Prot
      P50516
      Related
      ENSMUSP00000110314.3, ENSMUST00000114666.9
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43905765..43960064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521721.4XP_006521784.1  V-type proton ATPase catalytic subunit A isoform X1

      See identical proteins and their annotated locations for XP_006521784.1

      UniProtKB/Swiss-Prot
      P50516
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    Support Center