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    Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A [ Mus musculus (house mouse) ]

    Gene ID: 11964, updated on 5-Mar-2019

    Summary

    Official Symbol
    Atp6v1aprovided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit Aprovided by MGI
    Primary source
    MGI:MGI:1201780
    See related
    Ensembl:ENSMUSG00000052459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VA68; VPP2; Atp6a1; Atp6a2; AI647066; Atp6v1a1
    Expression
    Broad expression in cerebellum adult (RPKM 59.0), frontal lobe adult (RPKM 52.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See Atp6v1a in Genome Data Viewer
    Location:
    16; 16 B4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (44085404..44139711, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (44085517..44139132, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46552 Neighboring gene GRAM domain containing 1C Neighboring gene microRNA 3470b Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit Neighboring gene upstream transcription factor family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to increased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    myelin sheath HDA PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    V-type proton ATPase catalytic subunit A
    Names
    70-kDa subunit
    ATPase, H+ transporting, V1 subunit A, isoform 1
    ATPase, H+ transporting, V1 subunit A1
    ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, isoform 2
    ATPase, H+ transporting, lysosomal 70kD, V1 subunit A, isoform 1
    V-ATPase 69 kDa subunit
    V-ATPase subunit A
    lysosomal 70kDa
    vacuolar proton pump subunit alpha
    NP_031534.2
    XP_006521783.1
    XP_006521784.1
    XP_011244111.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358203.1NP_001345132.1  V-type proton ATPase catalytic subunit A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    2. NM_001358204.1NP_001345133.1  V-type proton ATPase catalytic subunit A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    3. NM_007508.6NP_031534.2  V-type proton ATPase catalytic subunit A

      See identical proteins and their annotated locations for NP_031534.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC125098
      Consensus CDS
      CCDS28182.1
      UniProtKB/Swiss-Prot
      P50516
      Related
      ENSMUSP00000110314.2, ENSMUST00000114666.8
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      44085404..44139711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521721.2XP_006521784.1  V-type proton ATPase catalytic subunit A isoform X1

      See identical proteins and their annotated locations for XP_006521784.1

      UniProtKB/Swiss-Prot
      P50516
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    2. XM_011245809.2XP_011244111.1  V-type proton ATPase catalytic subunit A isoform X1

      UniProtKB/Swiss-Prot
      P50516
      Related
      ENSMUSP00000066886.6, ENSMUST00000063661.12
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
    3. XM_006521720.3XP_006521783.1  V-type proton ATPase catalytic subunit A isoform X1

      UniProtKB/Swiss-Prot
      P50516
      Conserved Domains (1) summary
      TIGR01042
      Location:17609
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
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