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    Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [ Mus musculus (house mouse) ]

    Gene ID: 11938, updated on 12-Mar-2019

    Summary

    Official Symbol
    Atp2a2provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2provided by MGI
    Primary source
    MGI:MGI:88110
    See related
    Ensembl:ENSMUSG00000029467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik
    Expression
    Biased expression in heart adult (RPKM 1140.8), bladder adult (RPKM 124.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See Atp2a2 in Genome Data Viewer
    Location:
    5 62.38 cM; 5 F
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (122453513..122502225, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122903522..122952234, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32853 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene RIKEN cDNA 1700040P09 gene Neighboring gene intraflagellar transport 81 Neighboring gene STIP1 homology and U-Box containing protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ion homeostasis, organism-specific biosystem (from REACTOME)
      Ion homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
      Ion transport by P-type ATPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
      Reduction of cytosolic Ca++ levels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4195

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-transporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lutropin-choriogonadotropic hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proton-exporting ATPase activity, phosphorylative mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ER-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport from cytosol to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction by calcium ion signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of the force of heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sarcoplasmic reticulum calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    apical ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion-transporting ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    longitudinal sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane bounded cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2
    Names
    SERCA2a isoform
    SR Ca(2+)-ATPase 2
    calcium pump 2
    calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
    endoplasmic reticulum class 1/2 Ca(2+) ATPase
    sarco/endoplasmic reticulum Ca2+-ATPase 2
    NP_001103610.1
    NP_033852.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110140.3NP_001103610.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

      See identical proteins and their annotated locations for NP_001103610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (b), also known as SERCA2B.
      Source sequence(s)
      AJ131821, AK220538, CF742600, CJ162528
      Consensus CDS
      CCDS57378.1
      UniProtKB/Swiss-Prot
      O55143
      UniProtKB/TrEMBL
      Q5DTI2
      Related
      ENSMUSP00000031423.8, ENSMUST00000031423.9
      Conserved Domains (6) summary
      TIGR01116
      Location:53988
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:783986
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:472
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:605711
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419527
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_009722.3NP_033852.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

      See identical proteins and their annotated locations for NP_033852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.
      Source sequence(s)
      AK220538, BC054748, CJ162528
      Consensus CDS
      CCDS57379.1
      UniProtKB/Swiss-Prot
      O55143
      UniProtKB/TrEMBL
      Q5DTI2
      Related
      ENSMUSP00000136104.1, ENSMUST00000177974.7
      Conserved Domains (6) summary
      TIGR01116
      Location:53988
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:783986
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:472
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:605711
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419527
      Cation_ATPase; Cation transport ATPase (P-type)

    RNA

    1. NR_027838.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents a longer 3' UTR, compared to variant 1. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK220538, BC054531, CJ162528

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      122453513..122502225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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