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    Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [ Mus musculus (house mouse) ]

    Gene ID: 11938, updated on 7-Sep-2021

    Summary

    Official Symbol
    Atp2a2provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2provided by MGI
    Primary source
    MGI:MGI:88110
    See related
    Ensembl:ENSMUSG00000029467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SER; SERC; SERCA2; SERCA2B; Serca2a; D5Wsu150; D5Wsu150e; mKIAA4195; 9530097L16Rik
    Expression
    Biased expression in heart adult (RPKM 1140.8), bladder adult (RPKM 124.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atp2a2 in Genome Data Viewer
    Location:
    5 62.38 cM; 5 F
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122591576..122640288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122453513..122502225, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122903522..122952234, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32853 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene RIKEN cDNA 1700040P09 gene Neighboring gene predicted gene, 22965

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4195

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables P-type calcium transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type ion transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lutropin-choriogonadotropic hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ER-nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import into sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport from cytosol to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organelle localization by membrane tethering ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of endoplasmic reticulum calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of the force of heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sarcoplasmic reticulum calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sarcoplasmic reticulum calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transition between fast and slow fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical ectoplasmic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium ion-transporting ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in longitudinal sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane bounded cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2
    Names
    SR Ca(2+)-ATPase 2
    calcium pump 2
    endoplasmic reticulum class 1/2 Ca(2+) ATPase
    sarco/endoplasmic reticulum Ca2+-ATPase 2
    NP_001103610.1
    NP_033852.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110140.3NP_001103610.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

      See identical proteins and their annotated locations for NP_001103610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (b), also known as SERCA2B.
      Source sequence(s)
      AJ131821, AK220538, CF742600, CJ162528
      Consensus CDS
      CCDS57378.1
      UniProtKB/Swiss-Prot
      O55143
      UniProtKB/TrEMBL
      Q5DTI2
      Related
      ENSMUSP00000031423.9, ENSMUST00000031423.10
      Conserved Domains (6) summary
      TIGR01116
      Location:53988
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:783986
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:472
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:605711
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419527
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_009722.3NP_033852.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

      See identical proteins and their annotated locations for NP_033852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.
      Source sequence(s)
      AK220538, BC054748, CJ162528
      Consensus CDS
      CCDS57379.1
      UniProtKB/Swiss-Prot
      O55143
      UniProtKB/TrEMBL
      Q5DTI2
      Related
      ENSMUSP00000136104.2, ENSMUST00000177974.8
      Conserved Domains (6) summary
      TIGR01116
      Location:53988
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93340
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:783986
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:472
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:605711
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:419527
      Cation_ATPase; Cation transport ATPase (P-type)

    RNA

    1. NR_027838.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents a longer 3' UTR, compared to variant 1. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK220538, BC054531, CJ162528

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      122591576..122640288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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