Format

Send to:

Choose Destination
    • Showing Current items.

    Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11933, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atp1b3provided by MGI
    Official Full Name
    ATPase, Na+/K+ transporting, beta 3 polypeptideprovided by MGI
    Primary source
    MGI:MGI:107788
    See related
    Ensembl:ENSMUSG00000032412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA409958; AI664000; AW212096
    Expression
    Ubiquitous expression in testis adult (RPKM 23.7), cerebellum adult (RPKM 12.0) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atp1b3 in Genome Data Viewer
    Location:
    9 E3.3; 9 50.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96214708..96246484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96332655..96364431, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (96233092..96264718, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glycerol kinase 5 (putative) Neighboring gene transcription factor Dp 2 Neighboring gene predicted gene, 39408 Neighboring gene predicted gene, 39409 Neighboring gene predicted gene, 40550 Neighboring gene predicted gene, 51656

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables P-type sodium:potassium-exchanging transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metal ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of sodium:potassium-exchanging ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-3
    Names
    ATPB-3
    ATPase, Na+/K+ beta 3 polypeptide
    Na K-ATPase beta-3 subunit
    sodium/potassium-dependent ATPase subunit beta-3
    NP_001344141.1
    NP_001344142.1
    NP_031528.1
    XP_030099890.1
    XP_030099891.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357212.1NP_001344141.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC117248
      Conserved Domains (1) summary
      cl08255
      Location:1242
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    2. NM_001357213.1NP_001344142.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC117248
      Conserved Domains (1) summary
      cl08255
      Location:1221
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    3. NM_007502.5NP_031528.1  sodium/potassium-transporting ATPase subunit beta-3 isoform 1

      See identical proteins and their annotated locations for NP_031528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC117248, AK151700, BQ174495
      Consensus CDS
      CCDS23414.1
      UniProtKB/Swiss-Prot
      P97370
      UniProtKB/TrEMBL
      Q544Q7
      Related
      ENSMUSP00000034983.6, ENSMUST00000034983.7
      Conserved Domains (1) summary
      cl08255
      Location:1278
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96214708..96246484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244030.1XP_030099890.1  sodium/potassium-transporting ATPase subunit beta-3 isoform X1

      Conserved Domains (1) summary
      cl08255
      Location:1221
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    2. XM_030244031.2XP_030099891.1  sodium/potassium-transporting ATPase subunit beta-3 isoform X1

      Conserved Domains (1) summary
      cl08255
      Location:1221
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    Support Center