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    Atox1 antioxidant 1 copper chaperone [ Mus musculus (house mouse) ]

    Gene ID: 11927, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atox1provided by MGI
    Official Full Name
    antioxidant 1 copper chaperoneprovided by MGI
    Primary source
    MGI:MGI:1333855
    See related
    Ensembl:ENSMUSG00000018585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atx1; AI256639
    Expression
    Ubiquitous expression in adrenal adult (RPKM 244.6), kidney adult (RPKM 226.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atox1 in Genome Data Viewer
    Location:
    11 B1.3; 11 33.07 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (55446643..55461138, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (55260145..55274640, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31842 Neighboring gene secreted acidic cysteine rich glycoprotein Neighboring gene predicted gene 12235 Neighboring gene GTPase activating protein (SH3 domain) binding protein 1 Neighboring gene predicted gene 12238

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper chaperone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    copper chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    copper ion export ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    copper transport protein ATOX1
    Names
    ATX1 (antioxidant protein 1) homolog 1
    metal transport protein ATX1
    NP_033850.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009720.3NP_033850.1  copper transport protein ATOX1

      See identical proteins and their annotated locations for NP_033850.1

      Status: VALIDATED

      Source sequence(s)
      BP773958, BQ747750
      Consensus CDS
      CCDS36158.1
      UniProtKB/Swiss-Prot
      O08997
      Related
      ENSMUSP00000104485.1, ENSMUST00000108857.1
      Conserved Domains (1) summary
      cd00371
      Location:563
      HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      55446643..55461138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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