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    Atf2 activating transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 11909, updated on 10-Jul-2021

    Summary

    Official Symbol
    Atf2provided by MGI
    Official Full Name
    activating transcription factor 2provided by MGI
    Primary source
    MGI:MGI:109349
    See related
    Ensembl:ENSMUSG00000027104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mXB; ATF-; CRE-; Creb; mXBP; Atf-2; Creb2; CRE-BP; D18875; D130078H02Rik; Tg(Gzma-Klra1)7Wum
    Expression
    Ubiquitous expression in CNS E14 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Atf2 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73646853..73723094, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73816509..73892677, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73654578..73730685, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 53265 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene predicted gene 10822 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) Neighboring gene predicted gene, 39851

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105211, MGC105222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables H2B histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables H4 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP response element binding protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leucine zipper domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in NK T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in abducens nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adipose tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in amelogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brainstem development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to anisomycin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to anisomycin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of cell density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in facial nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth plate cartilage chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth plate cartilage chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hepatocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in histone H2B acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H2B acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H4 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoglossal nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in motor neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurofilament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in white fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of H4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-2
    Names
    cAMP response element-binding protein CRE-BP1
    cAMP-dependent transcription factor ATF-2
    NP_001020264.1
    NP_001271298.1
    NP_001271299.1
    NP_001271300.1
    NP_001271301.1
    NP_001271302.1
    NP_001271303.1
    NP_001271305.1
    NP_033845.1
    XP_030102700.1
    XP_030102701.1
    XP_030102703.1
    XP_030102704.1
    XP_030102706.1
    XP_030102707.1
    XP_030102710.1
    XP_030102713.1
    XP_030102715.1
    XP_030102718.1
    XP_030102727.1
    XP_030102732.1
    XP_030102733.1
    XP_036013584.1
    XP_036013587.1
    XP_036013593.1
    XP_036013600.1
    XP_036013601.1
    XP_036013602.1
    XP_036013604.1
    XP_036013605.1
    XP_036013606.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025093.2NP_001020264.1  cyclic AMP-dependent transcription factor ATF-2 isoform 1

      See identical proteins and their annotated locations for NP_001020264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK051591, AL844581, AL845523, BC079883, BC082596
      Consensus CDS
      CCDS16134.1
      UniProtKB/Swiss-Prot
      P16951
      UniProtKB/TrEMBL
      Q543G2, Q640L6, Q68FE3
      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001284369.1NP_001271298.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

      See identical proteins and their annotated locations for NP_001271298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK035438, AK139515, AL844581, AL845523
      Consensus CDS
      CCDS16135.1
      UniProtKB/TrEMBL
      Q543G2, Q8CBR9
      Related
      ENSMUSP00000107641.3, ENSMUST00000112010.9
      Conserved Domains (3) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:144272
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001284370.1NP_001271299.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

      See identical proteins and their annotated locations for NP_001271299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AK035438, AK146839, AL844581, BY474294
      UniProtKB/TrEMBL
      Q8CBR9
      Related
      ENSMUST00000143714.8
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336377
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001284371.1NP_001271300.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

      See identical proteins and their annotated locations for NP_001271300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AK035438, AK146839, AL844581, BY474294
      UniProtKB/TrEMBL
      Q8CBR9
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336377
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001284372.1NP_001271301.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

      See identical proteins and their annotated locations for NP_001271301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523
      Consensus CDS
      CCDS71076.1
      UniProtKB/TrEMBL
      Q640L6
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001284373.1NP_001271302.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

      See identical proteins and their annotated locations for NP_001271302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, BC079883, BC082596
      Consensus CDS
      CCDS71076.1
      UniProtKB/TrEMBL
      Q640L6, Q68FE3
      Related
      ENSMUSP00000107647.3, ENSMUST00000112016.9
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_001284374.1NP_001271303.1  cyclic AMP-dependent transcription factor ATF-2 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523, BC082596, BC085137
      UniProtKB/TrEMBL
      Q640L6
      Related
      ENSMUST00000156455.8
      Conserved Domains (1) summary
      cd14687
      Location:101161
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    8. NM_001284376.1NP_001271305.1  cyclic AMP-dependent transcription factor ATF-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, contains an alternate in-frame exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523, BC079883, BC082596
      UniProtKB/TrEMBL
      Q640L6, Q68FE3
      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:289349
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    9. NM_009715.3NP_033845.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

      See identical proteins and their annotated locations for NP_033845.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK051591, AL844581, AL845523, BC079883
      Consensus CDS
      CCDS16135.1
      UniProtKB/TrEMBL
      Q543G2, Q68FE3
      Related
      ENSMUSP00000107638.2, ENSMUST00000112007.8
      Conserved Domains (3) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:144272
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73646853..73723094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246850.2XP_030102710.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336382
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:72331
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. XM_030246847.2XP_030102707.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

      Related
      ENSMUSP00000133632.2, ENSMUST00000173010.8
      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336382
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:72331
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    3. XM_030246840.2XP_030102700.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Related
      ENSMUSP00000107648.2, ENSMUST00000112017.8
      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_030246846.2XP_030102706.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

      Related
      ENSMUSP00000088311.5, ENSMUST00000090802.11
      Conserved Domains (3) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:144272
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    5. XM_036157694.1XP_036013587.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_030246872.1XP_030102732.1  cyclic AMP-dependent transcription factor ATF-2 isoform X6

      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:198258
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    7. XM_030246855.1XP_030102715.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_030246858.1XP_030102718.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_036157708.1XP_036013601.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

      Conserved Domains (3) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:144272
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    10. XM_030246843.2XP_030102703.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    11. XM_030246873.1XP_030102733.1  cyclic AMP-dependent transcription factor ATF-2 isoform X7

      Conserved Domains (2) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238284
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    12. XM_036157711.1XP_036013604.1  cyclic AMP-dependent transcription factor ATF-2 isoform X5

      Conserved Domains (2) summary
      cd12192
      Location:1552
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:206266
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    13. XM_036157707.1XP_036013600.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

      Conserved Domains (3) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:144272
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    14. XM_036157712.1XP_036013605.1  cyclic AMP-dependent transcription factor ATF-2 isoform X6

      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:198258
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    15. XM_036157709.1XP_036013602.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    16. XM_036157691.1XP_036013584.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Related
      ENSMUSP00000097588.5, ENSMUST00000100009.11
      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    17. XM_030246844.2XP_030102704.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    18. XM_030246853.2XP_030102713.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    19. XM_030246841.2XP_030102701.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    20. XM_030246867.1XP_030102727.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    21. XM_036157700.1XP_036013593.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      Conserved Domains (4) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      PRK14951
      Location:184312
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    22. XM_036157713.1XP_036013606.1  cyclic AMP-dependent transcription factor ATF-2 isoform X8

      Related
      ENSMUSP00000118560.2, ENSMUST00000128531.8
      Conserved Domains (2) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_004937562.1 RNA Sequence

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