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    PSTK phosphoseryl-tRNA kinase [ Homo sapiens (human) ]

    Gene ID: 118672, updated on 2-May-2024

    Summary

    Official Symbol
    PSTKprovided by HGNC
    Official Full Name
    phosphoseryl-tRNA kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:28578
    See related
    Ensembl:ENSG00000179988 MIM:611310; AllianceGenome:HGNC:28578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf89
    Summary
    Predicted to enable kinase activity and tRNA binding activity. Predicted to be involved in phosphorylation; selenocysteinyl-tRNA(Sec) biosynthetic process; and translation. Predicted to act upstream of or within selenocysteine incorporation. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1.8), testis (RPKM 1.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PSTK in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122980401..122990390)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123855384..123865385)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124739917..124749906)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2894 Neighboring gene uncharacterized LOC124902519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4143 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:124760713-124760899 Neighboring gene IKAROS family zinc finger 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4145 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:124776916-124777782 Neighboring gene acyl-CoA dehydrogenase short/branched chain Neighboring gene Sharpr-MPRA regulatory region 2783 Neighboring gene Sharpr-MPRA regulatory region 13327

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC35392

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-seryl-tRNA(Sec) kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    L-seryl-tRNA(Sec) kinase
    Names
    O-phosphoseryl-tRNA(Sec) kinase
    NP_001350460.1
    NP_699167.2
    XP_016871130.1
    XP_054220687.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363531.2NP_001350460.1  L-seryl-tRNA(Sec) kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS86153.1
      UniProtKB/TrEMBL
      H7BYY4
      Related
      ENSP00000384653.3, ENST00000406217.8
      Conserved Domains (1) summary
      TIGR03575
      Location:20357
      selen_PSTK_euk; L-seryl-tRNA(Sec) kinase, eukaryotic
    2. NM_153336.3NP_699167.2  L-seryl-tRNA(Sec) kinase isoform 2

      See identical proteins and their annotated locations for NP_699167.2

      Status: VALIDATED

      Source sequence(s)
      AC073585, BC035344
      Consensus CDS
      CCDS7633.1
      UniProtKB/Swiss-Prot
      Q6ZSS9, Q8IV42
      Related
      ENSP00000357882.3, ENST00000368887.7
      Conserved Domains (2) summary
      pfam13671
      Location:20212
      AAA_33; AAA domain
      cl17190
      Location:20301
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      122980401..122990390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015641.3XP_016871130.1  L-seryl-tRNA(Sec) kinase isoform X1

    RNA

    1. XR_001747018.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      123855384..123865385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364712.1XP_054220687.1  L-seryl-tRNA(Sec) kinase isoform X1

    RNA

    1. XR_008488161.1 RNA Sequence