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    Arnt aryl hydrocarbon receptor nuclear translocator [ Mus musculus (house mouse) ]

    Gene ID: 11863, updated on 28-Jun-2021

    Summary

    Official Symbol
    Arntprovided by MGI
    Official Full Name
    aryl hydrocarbon receptor nuclear translocatorprovided by MGI
    Primary source
    MGI:MGI:88071
    See related
    Ensembl:ENSMUSG00000015522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drnt; Hif1; ESTM4; Hif1b; bHLHe; ESTM42; W08714; bHLHe2; D3Ertd557; mKIAA4051; D3Ertd557e
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Arnt in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95341674..95404551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95434367..95497240)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95238312..95301162)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S16, mitochondrial pseudogene Neighboring gene SET domain, bifurcated 1 pseudogene Neighboring gene cathepsin K Neighboring gene predicted gene, 40096

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4051

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables nuclear receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to toxic substance TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of aryl hydrocarbon receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    aryl hydrocarbon receptor nuclear translocator
    Names
    HIF-1-beta
    HIF1-beta
    dioxin receptor, nuclear translocator
    hypoxia-inducible factor 1-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037737.2NP_001032826.1  aryl hydrocarbon receptor nuclear translocator isoform a

      See identical proteins and their annotated locations for NP_001032826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC092203, AK145415, AK153355, CJ183661
      Consensus CDS
      CCDS17614.1
      UniProtKB/Swiss-Prot
      P53762
      UniProtKB/TrEMBL
      Q3ULM2
      Related
      ENSMUSP00000099810.5, ENSMUST00000102749.11
      Conserved Domains (5) summary
      smart00091
      Location:166230
      PAS; PAS domain
      cd00130
      Location:362458
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:91143
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:163269
      PAS; PAS fold
      pfam14598
      Location:362462
      PAS_11; PAS domain
    2. NM_009709.4NP_033839.2  aryl hydrocarbon receptor nuclear translocator isoform b

      See identical proteins and their annotated locations for NP_033839.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon, as compared to variant 1. The encoded isoform b lacks an internal segment, as compared to isoform a.
      Source sequence(s)
      AC092203, AK145415, CJ183661
      Consensus CDS
      CCDS38546.1
      UniProtKB/TrEMBL
      Q3ULM2
      Related
      ENSMUSP00000088313.6, ENSMUST00000090804.12
      Conserved Domains (5) summary
      smart00091
      Location:151215
      PAS; PAS domain
      cd00130
      Location:347443
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00010
      Location:76128
      HLH; Helix-loop-helix DNA-binding domain
      pfam00989
      Location:148254
      PAS; PAS fold
      pfam14598
      Location:347447
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95341674..95404551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500931.5XP_006500994.1  aryl hydrocarbon receptor nuclear translocator isoform X2

      Related
      ENSMUSP00000102779.2, ENSMUST00000107161.8
      Conserved Domains (3) summary
      pfam00989
      Location:148254
      PAS; PAS fold
      pfam14598
      Location:347447
      PAS_11; PAS domain
      cd18947
      Location:71135
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    2. XM_006500930.5XP_006500993.1  aryl hydrocarbon receptor nuclear translocator isoform X1

      Conserved Domains (3) summary
      pfam00989
      Location:163269
      PAS; PAS fold
      pfam14598
      Location:362462
      PAS_11; PAS domain
      cd18947
      Location:86150
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    3. XM_006500933.4XP_006500996.1  aryl hydrocarbon receptor nuclear translocator isoform X5

      Conserved Domains (3) summary
      smart00091
      Location:362415
      PAS; PAS domain
      pfam00989
      Location:163269
      PAS; PAS fold
      cd18947
      Location:86150
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    4. XM_030252391.1XP_030108251.1  aryl hydrocarbon receptor nuclear translocator isoform X3

      Conserved Domains (3) summary
      pfam00989
      Location:97203
      PAS; PAS fold
      pfam14598
      Location:296396
      PAS_11; PAS domain
      cd18947
      Location:2084
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    5. XM_030252392.1XP_030108252.1  aryl hydrocarbon receptor nuclear translocator isoform X4

      Conserved Domains (3) summary
      pfam00989
      Location:59165
      PAS; PAS fold
      pfam14598
      Location:258358
      PAS_11; PAS domain
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    6. XM_030252393.1XP_030108253.1  aryl hydrocarbon receptor nuclear translocator isoform X6

      Conserved Domains (4) summary
      pfam00989
      Location:161267
      PAS; PAS fold
      pfam10428
      Location:562703
      SOG2; RAM signalling pathway protein
      pfam14598
      Location:360460
      PAS_11; PAS domain
      cd18947
      Location:84148
      bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

    RNA

    1. XR_001783643.3 RNA Sequence

    2. XR_001783644.3 RNA Sequence

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